A Computationally Designed Prefusion Stabilized Human Metapneumovirus Fusion Protein Vaccine Antigen Elicited a Potent Neutralization Response

A Computationally Designed Prefusion Stabilized Human Metapneumovirus Fusion Protein Vaccine Antigen Elicited a Potent Neutralization Response

<b>Background/Objectives:</b> Human metapneumovirus (hMPV) is a leading cause of respiratory infections in the elderly, with high morbidity and mortality and with no vaccines or specific therapies available. The primary protective antigen of hMPV is the fusion protein, and its prefusion...

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Main Authors: Michael Kishko, Antonia Stuebler, Sukanya Sasmal, Yvonne Chan, Dean Huang, Christopher Reyes, Jasmine Lin, Owen Price, Ana Kume, Katie Zong, Christine Bricault, Judith Alamares-Sapuay, Linong Zhang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
computational design
hMPV
subunit vaccine
prefusion stabilization
Online Access:https://www.mdpi.com/2076-393X/13/5/523
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