Advances in Pathophysiology and Novel Therapeutic Strategies for Coronary No-Reflow Phenomenon

Advances in Pathophysiology and Novel Therapeutic Strategies for Coronary No-Reflow Phenomenon

Coronary no-reflow (CNR) is the failure of blood to reperfuse ischemic myocardial tissue after restoration of the vasculature. CNR poses a significant clinical challenge in the treatment of patients with ST-segment elevation myocardial infarction (STEMI), as it increases mortality and the risk of ma...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hubert Borzuta, Wiktor Kociemba, Oliwia Bochenek, Monika Jarowicz, Agnieszka Wsół
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Biomedicines
Subjects:	coronary no-reflow myocardial infarction animal models pathophysiology ischemia/reperfusion injury microvascular obstruction
Online Access:	https://www.mdpi.com/2227-9059/13/7/1716
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The no-reflow phenomenon: current treatment and prevention strategies
by: S. V. Dil, et al.
Published: (2025-04-01)

NO-REFLOW PHENOMENON IN THE PRACTICE OF AN ENDOVASCULAR SURGEON
by: A. M. Gerasimov, et al.
Published: (2016-06-01)

PRIMARY ANGIOPLASTICS AND PHARMACOINVASIVE REPERFUSION IN MYOCARDIAL INFARCTION: IMPACT ON CLINICAL OUTCOMES AND NO-REFLOW PHENOMENON
by: E. V. Vyshlov, et al.
Published: (2015-02-01)

No-reflow phenomenon and reperfusion injury. Mechanisms and treatment
by: M. Yu. Gilyarov, et al.
Published: (2022-03-01)

Pharmacological correction of no-reflow phenomenon in myocardial infarction treatment
by: T. Yu. Mamonova, et al.
Published: (2009-04-01)

Prognostic value of no-reflow phenomenon in myocardial infarction: the role of the severity of ischemic damage
by: A. A. Frolov, et al.
Published: (2025-01-01)

Intracoronary epinephrine and verapamil in the refractory no-reflow phenomenon in patients with acute myocardial infarction
by: S. V. Dil, et al.
Published: (2022-01-01)

Effectiveness of deferred coronary artery stenting in the prevention of no-reflow in patients with acute ST-segment elevation myocardial infarction
by: A. V. Azarov, et al.
Published: (2021-03-01)

Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications
by: Mehdi Karasu, et al.
Published: (2024-10-01)

Phenotypes of coronary microvascular obstruction phenomenon (no-reflow) during percutaneous coronary interventions in myocardial infarction
by: A. A. Frolov, et al.
Published: (2024-01-01)

Effectiveness of Glucocorticoids in the No-Reflow Phenomenon in STEMI Patients
by: Maksim Y. Sokolov, et al.
Published: (2025-03-01)

Predictors of the no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction due to stenotic coronary artery disease
by: O. O. Khaniukov, et al.
Published: (2025-04-01)

Usefulness of platelet mass index in the prediction of angiographic no-reflow in patients with acute ST-segment elevation myocardial infarction
by: Erdoğan Sökmen, et al.
Published: (2025-05-01)

Role of biomarkers of myocardial injury and inflammation in predicting ischemia-reperfusion injury in patients with ST-segment elevation acute coronary syndrome undergoing endovascular revascularization
by: T. V. Rusak, et al.
Published: (2021-12-01)

Clinical factors associated with the no/slow-reflow phenomenon in patients with acute coronary syndrome
by: E. V. Konstantinova, et al.
Published: (2024-03-01)

Myocardial ischemia – reperfusion injury
by: S. V. Salo, et al.
Published: (2023-10-01)

Which сlinical, laboratory, and instrumental factors are associated with the development of the no-reflow phenomenon in patients with acute coronary syndrome?
by: E. V. Konstantinova, et al.
Published: (2025-08-01)

Antiedemic Effect of the Myosin Light Chain Kinase Inhibitor PIK7 in the Rat Model of Myocardial Ischemia Reperfusion Injury
by: Dmitry L. Sonin, et al.
Published: (2025-01-01)

Clinical, laboratory, and procedural predictors of slow flow/no reflow phenomenon after emergency percutaneous coronary interventions in ST-elevated myocardial infarction
by: Fatemeh Bamarinejad, et al.
Published: (2024-11-01)

«No-reflow» phenomenon and risk factors associated with its development after primary percutaneous coronary interventions in patients with ST elevation myocardial infarction
by: V.І. Tseluyko, et al.
Published: (2018-09-01)

The impact of alpha lipoic acid administration on oxidative stress markers and occurrence of no-reflow phenomenon in post myocardial infarction patients
by: Omar R. Elsayed, et al.
Published: (2025-05-01)

The Application of Coronary Contrast Emptying Time in Diagnosing Coronary Slow Flow Phenomenon: A Serial Case Report
by: Yudhie Tanta, et al.
Published: (2023-01-01)

Adenosine as an Adjunctive Therapy for Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by: Xue-Mei Feng, et al.
Published: (2025-02-01)

Non-ST-elevation myocardial infarction: dual etiology, twoway therapy
by: Mihály Medvegy, et al.
Published: (2025-07-01)

Delayed endovascular surgery in patients with acute ST-segment elevation myocardial infarction due to massive culprit arterial thrombosis in the prevention of slow/no-reflow phenomenon
by: A. V. Azarov, et al.
Published: (2021-09-01)

Protective effect of exercise induced metabolite-3 in ischemia-reperfusion injury
by: Zijie CHENG, et al.
Published: (2025-06-01)

Mechanical complications of myocardial infarction: basic aspects of pathogenesis and approaches to surgical treatment
by: L. D. Shengelia, et al.
Published: (2023-07-01)

Drug-Induced Myocardial Infarction: A Review of Pharmacological Triggers and Pathophysiological Mechanisms
by: Ioana Boarescu, et al.
Published: (2024-12-01)

Cardioprotective effect of lithium ascorbate in an <i>in vivo</i> model of myocardial infarction
by: E. V. Plotnikov, et al.
Published: (2024-10-01)

Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model
by: David Boll, et al.
Published: (2025-07-01)

Thrombus aspiration in patients with ST-segment elevation myocardial infarction: a literature review
by: V. V. Ryabov, et al.
Published: (2023-09-01)

Novel Aspects of Cardiac Ischemia and Reperfusion Injury Mechanisms
by: T. A. Yagudin, et al.
Published: (2019-01-01)

Hydroxysafflor yellow A for ischemic heart diseases: a systematic review and meta-analysis of animal experiments
by: Tianshi Mao, et al.
Published: (2025-04-01)

Downregulation of Gldc attenuates myocardial ischemia reperfusion injury in vitro by modulating Akt and NF-κB signalings
by: Lian Shuang, et al.
Published: (2025-01-01)

Mechanisms of the cardioprotective effect of lithium
by: A. V. Mukhomedzyanov, et al.
Published: (2025-04-01)

Clinical manifestations and basic mechanisms of myocardial ischemia/reperfusion injury
by: Chiu-Fen Yang
Published: (2018-01-01)

The Impact of Baseplate Bow on Vacuum Reflow Soldering
by: 曾雄, et al.
Published: (2011-01-01)

Relationship Between Infarct Artery, Myocardial Injury, and Outcomes After Primary Percutaneous Coronary Intervention in ST‐Segment–Elevation Myocardial Infarction
by: Suzanne de Waha, et al.
Published: (2024-09-01)

Pathogenesis and clinical significance of reperfusion arrhythmias in acute myocardial infarctio
by: V. E. Oleynikov, et al.
Published: (2024-10-01)

Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies
by: Yuting Duan, et al.
Published: (2025-08-01)