RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias
Ventricular arrhythmias are one of the most common causes of death in developed countries. The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death. To date, the ejection fraction is the only approved clinical variable used to determine suitabilit...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/2868604 |
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| author | Francesca Galati Antonio Galati Serafina Massari |
| author_facet | Francesca Galati Antonio Galati Serafina Massari |
| author_sort | Francesca Galati |
| collection | DOAJ |
| description | Ventricular arrhythmias are one of the most common causes of death in developed countries. The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death. To date, the ejection fraction is the only approved clinical variable used to determine suitability for defibrillator placement in subjects with heart failure. The purpose of this study was to assess whether genetic polymorphisms found in the ryanodine receptor type 2 (Q2958R) and histidine-rich calcium-binding protein (S96A) might serve as markers for arrhythmias. Genotyping was performed in 235 patients treated with defibrillator for primary and secondary prevention of arrhythmias. No significant association was found between the S96A polymorphism and arrhythmia onset, whereas the QQ2958 genotype in the ryanodine receptor gene was correlated with an increased risk of life-threatening arrhythmias. Concurrent stressor conditions, such as hypertension, seem to increase this effect. Our findings might help to better identify patients who could benefit from defibrillator implantation. |
| format | Article |
| id | doaj-art-4e8aaff4261245dd8dc5c78a54f27509 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-4e8aaff4261245dd8dc5c78a54f275092025-08-20T03:36:39ZengWileyCardiology Research and Practice2090-80162090-05972016-01-01201610.1155/2016/28686042868604RyR2 QQ2958 Genotype and Risk of Malignant Ventricular ArrhythmiasFrancesca Galati0Antonio Galati1Serafina Massari2Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyDepartment of Cardiology, “Card. G. Panico” Hospital, Tricase, 73039 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, ItalyVentricular arrhythmias are one of the most common causes of death in developed countries. The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death. To date, the ejection fraction is the only approved clinical variable used to determine suitability for defibrillator placement in subjects with heart failure. The purpose of this study was to assess whether genetic polymorphisms found in the ryanodine receptor type 2 (Q2958R) and histidine-rich calcium-binding protein (S96A) might serve as markers for arrhythmias. Genotyping was performed in 235 patients treated with defibrillator for primary and secondary prevention of arrhythmias. No significant association was found between the S96A polymorphism and arrhythmia onset, whereas the QQ2958 genotype in the ryanodine receptor gene was correlated with an increased risk of life-threatening arrhythmias. Concurrent stressor conditions, such as hypertension, seem to increase this effect. Our findings might help to better identify patients who could benefit from defibrillator implantation.http://dx.doi.org/10.1155/2016/2868604 |
| spellingShingle | Francesca Galati Antonio Galati Serafina Massari RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias Cardiology Research and Practice |
| title | RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias |
| title_full | RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias |
| title_fullStr | RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias |
| title_full_unstemmed | RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias |
| title_short | RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias |
| title_sort | ryr2 qq2958 genotype and risk of malignant ventricular arrhythmias |
| url | http://dx.doi.org/10.1155/2016/2868604 |
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