Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils

Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils

IntroductionOvarian cancer is a lethal disease with low survival rates for women diagnosed in advanced stages. Current cancer immunotherapies are not efficient in ovarian cancer, and there is therefore a significant need for novel treatment options. The β-galactoside-binding lectin, Galectin-3, is i...

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Bibliographic Details
Main Authors: Veronika Karlsson, Ebba Stål, Emma Stoopendahl, Anton Ivarsson, Hakon Leffler, Maria Lycke, Martina Sundqvist, Karin Sundfeldt, Karin Christenson, Elin Bernson
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
galectin-3
ovarian cancer
NK cells
neutrophils
tumor immunology
ROS release
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506236/full
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