Early social deficits in TgF344-AD rats are accompanied by sex-specific parvalbumin-positive interneuron reduction and altered brain oscillations in the hippocampal CA2

Social withdrawal and deficits in social cognition are hallmarks of Alzheimer's disease (AD). While early deficits in social behavior and memory have been documented in mouse AD models, they remain understudied in rat models. Early-stage AD is accompanied by dysfunction of parvalbumin-positive...

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Main Authors: Daniela Černotová, Karolína Hrůzová, Jan Touš, Radek Janča, Aleš Stuchlík, David Levčík, Jan Svoboda
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neurobiology of Disease
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000919
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