Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature
Hepatosplenic T-cell lymphoma (HSTL) is a rare and aggressive mature T-cell lymphoma characterized by hepatosplenic involvement. It usually occurs de novo in adolescents and young adults (AYA) and has been most commonly reported in the setting of immunosuppression. Most cases present with proliferat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Human Pathology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772736X25000210 |
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| author | Rodolfo Garza-Morales Isabela Wen-Chi Chang Allison Rosenthal Jiehao Zhou |
| author_facet | Rodolfo Garza-Morales Isabela Wen-Chi Chang Allison Rosenthal Jiehao Zhou |
| author_sort | Rodolfo Garza-Morales |
| collection | DOAJ |
| description | Hepatosplenic T-cell lymphoma (HSTL) is a rare and aggressive mature T-cell lymphoma characterized by hepatosplenic involvement. It usually occurs de novo in adolescents and young adults (AYA) and has been most commonly reported in the setting of immunosuppression. Most cases present with proliferation of cytotoxic T-cells of TCRγδ type with a unique gene mutation profile. Due to rarity of this disease, there is no standard of care treatment, and outcomes are usually poor in the absence of stem cell transplant. In this case, we report an unusual presentation of HSTL of TCRαβ type in an elderly patient status post treatment of an indolent B-cell lymphoma. |
| format | Article |
| id | doaj-art-4e792f78bf024764a47fba7b0c1aaecd |
| institution | Kabale University |
| issn | 2772-736X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology Reports |
| spelling | doaj-art-4e792f78bf024764a47fba7b0c1aaecd2025-08-24T05:15:31ZengElsevierHuman Pathology Reports2772-736X2025-09-014130078910.1016/j.hpr.2025.300789Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literatureRodolfo Garza-Morales0Isabela Wen-Chi Chang1Allison Rosenthal2Jiehao Zhou3Department of Medicine, Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USADepartment of Medicine, Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USADepartment of Medicine, Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USADepartment of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Phoenix, AZ, USA; Corresponding author.Hepatosplenic T-cell lymphoma (HSTL) is a rare and aggressive mature T-cell lymphoma characterized by hepatosplenic involvement. It usually occurs de novo in adolescents and young adults (AYA) and has been most commonly reported in the setting of immunosuppression. Most cases present with proliferation of cytotoxic T-cells of TCRγδ type with a unique gene mutation profile. Due to rarity of this disease, there is no standard of care treatment, and outcomes are usually poor in the absence of stem cell transplant. In this case, we report an unusual presentation of HSTL of TCRαβ type in an elderly patient status post treatment of an indolent B-cell lymphoma.http://www.sciencedirect.com/science/article/pii/S2772736X25000210HSTLHepatosplenomegalyTCRαβCHOEP |
| spellingShingle | Rodolfo Garza-Morales Isabela Wen-Chi Chang Allison Rosenthal Jiehao Zhou Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature Human Pathology Reports HSTL Hepatosplenomegaly TCRαβ CHOEP |
| title | Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature |
| title_full | Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature |
| title_fullStr | Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature |
| title_full_unstemmed | Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature |
| title_short | Hepatosplenic T-cell lymphoma, αβ type, presenting in an elderly patient status post indolent B-cell lymphoma treatment: report of a case and review of the literature |
| title_sort | hepatosplenic t cell lymphoma αβ type presenting in an elderly patient status post indolent b cell lymphoma treatment report of a case and review of the literature |
| topic | HSTL Hepatosplenomegaly TCRαβ CHOEP |
| url | http://www.sciencedirect.com/science/article/pii/S2772736X25000210 |
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