Proteomics – The research frontier in periodontics
Periodontitis is an inflammatory condition resulting from the interplay between the infectious agents and host factors. Various protein molecules play a vital role in the initiation, progression and severity of periodontal diseases. The study of proteins as biomarkers in periodontal diseases has bee...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426815000068 |
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| author | Abhaya Gupta Vivek Govila Ashish Saini |
| author_facet | Abhaya Gupta Vivek Govila Ashish Saini |
| author_sort | Abhaya Gupta |
| collection | DOAJ |
| description | Periodontitis is an inflammatory condition resulting from the interplay between the infectious agents and host factors. Various protein molecules play a vital role in the initiation, progression and severity of periodontal diseases. The study of proteins as biomarkers in periodontal diseases has been highlighted during the last few years. In periodontitis multiple bacteria derived (e.g. collagen degrading enzymes, elastase like enzymes etc) and host derived mediators (eg. PGE2, TNF, IL1, IL6, MMP's etc) expressed in the saliva and gingival crevicular fluid, can be utilized as diagnostic markers for the disease. Another significant development regarding human genes and proteins has been the discovery of potential new drugs for the treatment of periodontal diseases. Therefore the information of the proteins involved in the pathogenesis of periodontal diseases can be utilized for its diagnosis, prevention and treatment. |
| format | Article |
| id | doaj-art-4e78af4abca7478a91ce83f14acab0c1 |
| institution | DOAJ |
| issn | 2212-4268 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-4e78af4abca7478a91ce83f14acab0c12025-08-20T02:50:26ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682015-01-0151465210.1016/j.jobcr.2015.01.001Proteomics – The research frontier in periodonticsAbhaya Gupta0Vivek Govila1Ashish Saini2MDS (IIIrd Year) Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India; Corresponding author. Tel.: +91 8052904736 (mobile), +91 9415009076 (mobile).MDS (Professor & Head of Department), Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, IndiaMDS (Reader), Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, IndiaPeriodontitis is an inflammatory condition resulting from the interplay between the infectious agents and host factors. Various protein molecules play a vital role in the initiation, progression and severity of periodontal diseases. The study of proteins as biomarkers in periodontal diseases has been highlighted during the last few years. In periodontitis multiple bacteria derived (e.g. collagen degrading enzymes, elastase like enzymes etc) and host derived mediators (eg. PGE2, TNF, IL1, IL6, MMP's etc) expressed in the saliva and gingival crevicular fluid, can be utilized as diagnostic markers for the disease. Another significant development regarding human genes and proteins has been the discovery of potential new drugs for the treatment of periodontal diseases. Therefore the information of the proteins involved in the pathogenesis of periodontal diseases can be utilized for its diagnosis, prevention and treatment.http://www.sciencedirect.com/science/article/pii/S2212426815000068ProteomeGenomePeriodontitisPorphyromonas gingivalisBiomarkers |
| spellingShingle | Abhaya Gupta Vivek Govila Ashish Saini Proteomics – The research frontier in periodontics Journal of Oral Biology and Craniofacial Research Proteome Genome Periodontitis Porphyromonas gingivalis Biomarkers |
| title | Proteomics – The research frontier in periodontics |
| title_full | Proteomics – The research frontier in periodontics |
| title_fullStr | Proteomics – The research frontier in periodontics |
| title_full_unstemmed | Proteomics – The research frontier in periodontics |
| title_short | Proteomics – The research frontier in periodontics |
| title_sort | proteomics the research frontier in periodontics |
| topic | Proteome Genome Periodontitis Porphyromonas gingivalis Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2212426815000068 |
| work_keys_str_mv | AT abhayagupta proteomicstheresearchfrontierinperiodontics AT vivekgovila proteomicstheresearchfrontierinperiodontics AT ashishsaini proteomicstheresearchfrontierinperiodontics |