Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease
Background Chronic kidney disease (CKD) is a prevalent chronic, non-communicable disease. The long-term health effects of dietary live microbes, primarily probiotics, on CKD patients remain insufficiently understood. This study aims to investigate the association between dietary intake of live micro...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2449196 |
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| author | Debin Chen Yongju Ye Yining Li Erxu Xue Qijun Zhang Youlan Chen Jianhui Zhao |
| author_facet | Debin Chen Yongju Ye Yining Li Erxu Xue Qijun Zhang Youlan Chen Jianhui Zhao |
| author_sort | Debin Chen |
| collection | DOAJ |
| description | Background Chronic kidney disease (CKD) is a prevalent chronic, non-communicable disease. The long-term health effects of dietary live microbes, primarily probiotics, on CKD patients remain insufficiently understood. This study aims to investigate the association between dietary intake of live microbes and long-term health outcomes among individuals with CKD.Methods Utilizing the National Health and Nutrition Examination Survey (NHANES) database, Cox regression analysis assessed the association between medium and high categories dietary live microbe intake and health outcomes (all-cause, cardiovascular disease [CVD], and cancer-related mortality) in CKD patients.Results A total of 3,646 CKD patients were enrolled. During the follow-up period, 1,593 all-cause mortality events were recorded, including 478 CVD deaths and 268 cancer deaths. In the fully adjusted model, compared to CKD patients in the lowest quartile (quartile 1) of live microbes intake, those in quartiles 3 and 4 exhibited a 20% and 26% reduced risk of all-cause mortality, with hazard ratios (HR) of 0.80 (95% confidence interval, CI: 0.69, 0.94) and 0.74 (95% CI: 0.62, 0.90), respectively. Additionally, compared to those with low live microbe intake (quartile 1), higher live microbe intake in quartile 4 was associated with a 37% reduction in the risk of CVD mortality for CKD patients, with an HR of 0.63 (95% CI: 0.45, 0.88). Consistent results were observed in subgroup and sensitivity analyses. A significant negative association was observed between live microbe intake and the risk of all-cause mortality as well as CVD mortality in the CKD population, with a p-value for trend < 0.05.Conclusion Our study indicated that high dietary live microbe intake could mitigate the risk of all-cause and CVD mortality in CKD patients. These findings support the inclusion of live microbes in dietary recommendations, highlighting their significant roles in CKD. |
| format | Article |
| id | doaj-art-4e704a213c81442eb4881b836ba48bf3 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-4e704a213c81442eb4881b836ba48bf32025-01-07T05:19:18ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2024.2449196Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney diseaseDebin Chen0Yongju Ye1Yining Li2Erxu Xue3Qijun Zhang4Youlan Chen5Jianhui Zhao6Chronic and Endemic Disease Prevention and Control Division, Xiamen Center for Disease Control and Prevention, Xiamen, ChinaDepartment of Gynaecology, Lishui Hospital of Traditional Chinese Medicine, Lishui, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, ChinaNursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCardiovascular Department, The Affiliated People’s Hospital of Ningbo University, Ningbo, ChinaChronic and Endemic Disease Prevention and Control Division, Xiamen Center for Disease Control and Prevention, Xiamen, ChinaChronic and Endemic Disease Prevention and Control Division, Xiamen Center for Disease Control and Prevention, Xiamen, ChinaBackground Chronic kidney disease (CKD) is a prevalent chronic, non-communicable disease. The long-term health effects of dietary live microbes, primarily probiotics, on CKD patients remain insufficiently understood. This study aims to investigate the association between dietary intake of live microbes and long-term health outcomes among individuals with CKD.Methods Utilizing the National Health and Nutrition Examination Survey (NHANES) database, Cox regression analysis assessed the association between medium and high categories dietary live microbe intake and health outcomes (all-cause, cardiovascular disease [CVD], and cancer-related mortality) in CKD patients.Results A total of 3,646 CKD patients were enrolled. During the follow-up period, 1,593 all-cause mortality events were recorded, including 478 CVD deaths and 268 cancer deaths. In the fully adjusted model, compared to CKD patients in the lowest quartile (quartile 1) of live microbes intake, those in quartiles 3 and 4 exhibited a 20% and 26% reduced risk of all-cause mortality, with hazard ratios (HR) of 0.80 (95% confidence interval, CI: 0.69, 0.94) and 0.74 (95% CI: 0.62, 0.90), respectively. Additionally, compared to those with low live microbe intake (quartile 1), higher live microbe intake in quartile 4 was associated with a 37% reduction in the risk of CVD mortality for CKD patients, with an HR of 0.63 (95% CI: 0.45, 0.88). Consistent results were observed in subgroup and sensitivity analyses. A significant negative association was observed between live microbe intake and the risk of all-cause mortality as well as CVD mortality in the CKD population, with a p-value for trend < 0.05.Conclusion Our study indicated that high dietary live microbe intake could mitigate the risk of all-cause and CVD mortality in CKD patients. These findings support the inclusion of live microbes in dietary recommendations, highlighting their significant roles in CKD.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2449196Chronic kidney diseaselive microbesall-cause mortalitycardiovascular disease mortalitycancer-related mortality |
| spellingShingle | Debin Chen Yongju Ye Yining Li Erxu Xue Qijun Zhang Youlan Chen Jianhui Zhao Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease Renal Failure Chronic kidney disease live microbes all-cause mortality cardiovascular disease mortality cancer-related mortality |
| title | Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease |
| title_full | Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease |
| title_fullStr | Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease |
| title_full_unstemmed | Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease |
| title_short | Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease |
| title_sort | association of live microbes intake and risk of all cause cardiovascular disease and cancer related mortality in patients with chronic kidney disease |
| topic | Chronic kidney disease live microbes all-cause mortality cardiovascular disease mortality cancer-related mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2449196 |
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