Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions
Bacterial diseases such as motile Aeromonas septicemia are major constraints on aquaculture. This study evaluated the efficacy of oral oxolinic acid (OA) therapy at 12 mg kg biomass−1 day−1 for seven days to treat Aeromonas veronii-Av-F (AV) infection in Oreochromis niloticus. The lethal dose of AV...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2025-03-01
|
| Series: | Fisheries & Aquatic Life |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/aopf-2025-0001 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849305998089519104 |
|---|---|
| author | Sinha Priyanka Abraham Thangapalam Jawahar Sen Arya Sharon Joshi Das Ratnapriya Ghorai Arpan Boda Satyanarayana Patil Prasanna Kumar |
| author_facet | Sinha Priyanka Abraham Thangapalam Jawahar Sen Arya Sharon Joshi Das Ratnapriya Ghorai Arpan Boda Satyanarayana Patil Prasanna Kumar |
| author_sort | Sinha Priyanka |
| collection | DOAJ |
| description | Bacterial diseases such as motile Aeromonas septicemia are major constraints on aquaculture. This study evaluated the efficacy of oral oxolinic acid (OA) therapy at 12 mg kg biomass−1 day−1 for seven days to treat Aeromonas veronii-Av-F (AV) infection in Oreochromis niloticus. The lethal dose of AV for 50% mortality was determined to be 1.81 ×108 cells fish−1. Following intramuscular AV infection at 2.47 × 108 cells fish−1, OA treatment significantly reduced fish mortality and accelerated wound healing. AV infection caused notable changes in biochemical, and hematological parameters, erythrocyte morphology, and histopathological damage to liver and kidney tissues. However, OA therapy facilitated normalizing these parameters more rapidly than in untreated fish, including erythrocyte morphology and histopathological alterations. The study highlights the effectiveness of OA in treating AV infection in O. niloticus. However, available evidence cautions against its overuse and violations of regulations because of its critical importance in human medicine. |
| format | Article |
| id | doaj-art-4e6e54e915024bc8bc002e3a22859890 |
| institution | Kabale University |
| issn | 2545-059X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Fisheries & Aquatic Life |
| spelling | doaj-art-4e6e54e915024bc8bc002e3a228598902025-08-20T03:55:12ZengSciendoFisheries & Aquatic Life2545-059X2025-03-0133111810.2478/aopf-2025-0001Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesionsSinha Priyanka0Abraham Thangapalam Jawahar1Sen Arya2Sharon Joshi3Das Ratnapriya4Ghorai Arpan5Boda Satyanarayana6Patil Prasanna Kumar7Department of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaDepartment of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaDepartment of Fishery Economics and Statistics, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, West Bengal, IndiaAquatic Animal Health and Environment Division, ICAR-Central Institute of Brackishwater Aquaculture, Raja Annamalai Puram, Chennai 600028, Tamil Nadu, IndiaBacterial diseases such as motile Aeromonas septicemia are major constraints on aquaculture. This study evaluated the efficacy of oral oxolinic acid (OA) therapy at 12 mg kg biomass−1 day−1 for seven days to treat Aeromonas veronii-Av-F (AV) infection in Oreochromis niloticus. The lethal dose of AV for 50% mortality was determined to be 1.81 ×108 cells fish−1. Following intramuscular AV infection at 2.47 × 108 cells fish−1, OA treatment significantly reduced fish mortality and accelerated wound healing. AV infection caused notable changes in biochemical, and hematological parameters, erythrocyte morphology, and histopathological damage to liver and kidney tissues. However, OA therapy facilitated normalizing these parameters more rapidly than in untreated fish, including erythrocyte morphology and histopathological alterations. The study highlights the effectiveness of OA in treating AV infection in O. niloticus. However, available evidence cautions against its overuse and violations of regulations because of its critical importance in human medicine.https://doi.org/10.2478/aopf-2025-0001antibiotic treatmentaquaculturebacterial diseasehemato-biochemistrytissue architecturewound progression |
| spellingShingle | Sinha Priyanka Abraham Thangapalam Jawahar Sen Arya Sharon Joshi Das Ratnapriya Ghorai Arpan Boda Satyanarayana Patil Prasanna Kumar Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions Fisheries & Aquatic Life antibiotic treatment aquaculture bacterial disease hemato-biochemistry tissue architecture wound progression |
| title | Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions |
| title_full | Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions |
| title_fullStr | Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions |
| title_full_unstemmed | Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions |
| title_short | Oxolinic acid therapy: An effective way to reduce Aeromonas veronii infection in Oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions |
| title_sort | oxolinic acid therapy an effective way to reduce aeromonas veronii infection in oreochromis niloticus and improve biochemical and hematological parameters and histopathological lesions |
| topic | antibiotic treatment aquaculture bacterial disease hemato-biochemistry tissue architecture wound progression |
| url | https://doi.org/10.2478/aopf-2025-0001 |
| work_keys_str_mv | AT sinhapriyanka oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT abrahamthangapalamjawahar oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT senarya oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT sharonjoshi oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT dasratnapriya oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT ghoraiarpan oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT bodasatyanarayana oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions AT patilprasannakumar oxolinicacidtherapyaneffectivewaytoreduceaeromonasveroniiinfectioninoreochromisniloticusandimprovebiochemicalandhematologicalparametersandhistopathologicallesions |