Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation
Summary: Hematopoietic stem cells (HSCs) possess the capacity to regenerate the entire hematopoietic system. However, the precise HSC dynamics in the early post-transplantation phase remain an enigma. Clinically, the initial hematopoiesis in the post-transplantation period is critical, necessitating...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000129 |
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| author | Takao Yogo Hans Jiro Becker Takaharu Kimura Satoshi Iwano Takahiro Kuchimaru Atsushi Miyawaki Tomomasa Yokomizo Toshio Suda Atsushi Iwama Satoshi Yamazaki |
| author_facet | Takao Yogo Hans Jiro Becker Takaharu Kimura Satoshi Iwano Takahiro Kuchimaru Atsushi Miyawaki Tomomasa Yokomizo Toshio Suda Atsushi Iwama Satoshi Yamazaki |
| author_sort | Takao Yogo |
| collection | DOAJ |
| description | Summary: Hematopoietic stem cells (HSCs) possess the capacity to regenerate the entire hematopoietic system. However, the precise HSC dynamics in the early post-transplantation phase remain an enigma. Clinically, the initial hematopoiesis in the post-transplantation period is critical, necessitating strategies to accelerate hematopoietic recovery. Here, we uncovered the spatiotemporal dynamics of early active hematopoiesis, “hematopoietic cell inflation,” using a highly sensitive in vivo imaging system. Hematopoietic cell inflation occurs in three peaks in the spleen after transplantation, with common myeloid progenitors (CMPs), notably characterized by HSC-like signatures, playing a central role. Leveraging these findings, we developed expanded CMPs (exCMPs), which exhibit a gene expression pattern that selectively proliferates in the spleen and promotes hematopoietic expansion. Moreover, universal exCMPs supported early hematopoiesis in allogeneic transplantation. Human universal exCMPs have the potential to be a viable therapeutic enhancement for all HSC transplant patients. |
| format | Article |
| id | doaj-art-4e6e0507f1944b2cb76120da49a7a36a |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-4e6e0507f1944b2cb76120da49a7a36a2025-01-27T04:21:52ZengElsevierCell Reports2211-12472025-02-01442115241Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflationTakao Yogo0Hans Jiro Becker1Takaharu Kimura2Satoshi Iwano3Takahiro Kuchimaru4Atsushi Miyawaki5Tomomasa Yokomizo6Toshio Suda7Atsushi Iwama8Satoshi Yamazaki9Division of Cell Regulation, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Cell Engineering, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Corresponding authorDivision of Cell Regulation, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Cell Engineering, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, JapanDivision of Cell Regulation, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Cell Engineering, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, JapanInstitute for Tenure Track Promotion, University of Miyazaki, Miyazaki, JapanCenter for Molecular Medicine, Jichi Medical University, Shimotsuke, JapanLaboratory for Cell Function Dynamics, RIKEN Center for Brain Science, RIKEN, Saitama, JapanDepartment of Microscopic and Developmental Anatomy, Tokyo Women’s Medical University, Tokyo, JapanInternational Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan; Stem Cell Biology Institute of Hematology, Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, JapanDivision of Cell Regulation, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Cell Engineering, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory for Stem Cell Therapy, Faculty of Medicine, Tsukuba University, Ibaraki, Japan; Corresponding authorSummary: Hematopoietic stem cells (HSCs) possess the capacity to regenerate the entire hematopoietic system. However, the precise HSC dynamics in the early post-transplantation phase remain an enigma. Clinically, the initial hematopoiesis in the post-transplantation period is critical, necessitating strategies to accelerate hematopoietic recovery. Here, we uncovered the spatiotemporal dynamics of early active hematopoiesis, “hematopoietic cell inflation,” using a highly sensitive in vivo imaging system. Hematopoietic cell inflation occurs in three peaks in the spleen after transplantation, with common myeloid progenitors (CMPs), notably characterized by HSC-like signatures, playing a central role. Leveraging these findings, we developed expanded CMPs (exCMPs), which exhibit a gene expression pattern that selectively proliferates in the spleen and promotes hematopoietic expansion. Moreover, universal exCMPs supported early hematopoiesis in allogeneic transplantation. Human universal exCMPs have the potential to be a viable therapeutic enhancement for all HSC transplant patients.http://www.sciencedirect.com/science/article/pii/S2211124725000129CP: Stem cell research |
| spellingShingle | Takao Yogo Hans Jiro Becker Takaharu Kimura Satoshi Iwano Takahiro Kuchimaru Atsushi Miyawaki Tomomasa Yokomizo Toshio Suda Atsushi Iwama Satoshi Yamazaki Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation Cell Reports CP: Stem cell research |
| title | Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation |
| title_full | Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation |
| title_fullStr | Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation |
| title_full_unstemmed | Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation |
| title_short | Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation |
| title_sort | progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation |
| topic | CP: Stem cell research |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000129 |
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