Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
The main objective of this study was to investigate the association between CD4+ and CD8+ lymphocyte values and disease severity, need for oxygen therapy and disease outcomes.
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-07-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1246 |
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| author | Jovičić Biljana Popovska Raković Ivana Đorđević Nemanja Gavrilović Jagoda Čanović Predrag Marjanović Ružica Radojević Petrović Sara Milosavljević Katarina B. Divjak Ana Stanković Nenad Paunović Milan Milosavljević Miloš Z. |
| author_facet | Jovičić Biljana Popovska Raković Ivana Đorđević Nemanja Gavrilović Jagoda Čanović Predrag Marjanović Ružica Radojević Petrović Sara Milosavljević Katarina B. Divjak Ana Stanković Nenad Paunović Milan Milosavljević Miloš Z. |
| author_sort | Jovičić Biljana Popovska |
| collection | DOAJ |
| description | The main objective of this study was to investigate the association between CD4+ and CD8+ lymphocyte values and disease severity, need for oxygen therapy and disease outcomes. |
| format | Article |
| id | doaj-art-4e6e01f1c56a49d68a15ef7a1ed3bfb8 |
| institution | DOAJ |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-4e6e01f1c56a49d68a15ef7a1ed3bfb82025-08-20T03:08:35ZengDe GruyterOpen Medicine2391-54632025-07-012011024333110.1515/med-2025-1246Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19Jovičić Biljana Popovska0Raković Ivana1Đorđević Nemanja2Gavrilović Jagoda3Čanović Predrag4Marjanović Ružica Radojević5Petrović Sara6Milosavljević Katarina B.7Divjak Ana8Stanković Nenad9Paunović Milan10Milosavljević Miloš Z.11Department of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, Kragujevac, 34000, SerbiaDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaInstitute of Emergency Medicine, Kragujevac, 34000, SerbiaDepartment of Physical Medicine and Rehabilitation, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, SerbiaClinic for General Surgery, University Clinical Center Kragujevac, Kragujevac, 34000, SerbiaCenter for Pediatric Surgery, University Clinical Center Kragujevac, Kragujevac, 34000, SerbiaDepartment of Pathology, University Clinical Center Kragujevac, Kragujevac, 34000, SerbiaThe main objective of this study was to investigate the association between CD4+ and CD8+ lymphocyte values and disease severity, need for oxygen therapy and disease outcomes.https://doi.org/10.1515/med-2025-1246cd4-positive t-lymphocytescd8-positive t-lymphocytesseverity of illnessfatal outcomecovid-19 |
| spellingShingle | Jovičić Biljana Popovska Raković Ivana Đorđević Nemanja Gavrilović Jagoda Čanović Predrag Marjanović Ružica Radojević Petrović Sara Milosavljević Katarina B. Divjak Ana Stanković Nenad Paunović Milan Milosavljević Miloš Z. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19 Open Medicine cd4-positive t-lymphocytes cd8-positive t-lymphocytes severity of illness fatal outcome covid-19 |
| title | Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19 |
| title_full | Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19 |
| title_fullStr | Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19 |
| title_full_unstemmed | Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19 |
| title_short | Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19 |
| title_sort | decrease in cd4 and cd8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with covid 19 |
| topic | cd4-positive t-lymphocytes cd8-positive t-lymphocytes severity of illness fatal outcome covid-19 |
| url | https://doi.org/10.1515/med-2025-1246 |
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