Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy
AIM: To evaluate the efficacy and safety of intravitreal low-dose (1 mg) triamcinolone acetonide (TA) in Chinese acute nonarteritic anterior ischemic optic neuropathy (NAION) patients. METHODS: Twenty-eight eyes of 28 patients with acute NAION (<30d of visual acuity loss) were enrolled and given...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-04-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/4/20250413.pdf |
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| author | Zi-Jia Liu Xian Xu Ya-Nan Lyu Dong-Li Li Hao Zhou Yuan-Yuan Gong |
| author_facet | Zi-Jia Liu Xian Xu Ya-Nan Lyu Dong-Li Li Hao Zhou Yuan-Yuan Gong |
| author_sort | Zi-Jia Liu |
| collection | DOAJ |
| description | AIM: To evaluate the efficacy and safety of intravitreal low-dose (1 mg) triamcinolone acetonide (TA) in Chinese acute nonarteritic anterior ischemic optic neuropathy (NAION) patients. METHODS: Twenty-eight eyes of 28 patients with acute NAION (<30d of visual acuity loss) were enrolled and given intravitreal TA (IVTA) once. Visual field (VF), best corrected visual acuity (BCVA), retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, radial peripapillary capillary (RPC) density, and intraocular pressure (IOP) were evaluated at baseline and 7d, 1, 3, and 6mo after IVTA. RESULTS: VF and BCVA were significant improved during the follow-up according to the mean deviation (MD), visual field index (VFI), and Early Treatment Diabetic Retinopathy Study (ETDRS) scores (all P<0.001). There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset. The RNFL thickness, GCC thickness and RPC density were significantly decreased (all P<0.001). Temporary ocular hypertension was present in five eyes. CONCLUSION: Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage. However, optic nerve atrophy still existed. |
| format | Article |
| id | doaj-art-4e6727973e3743a59eced9bae334dc47 |
| institution | DOAJ |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-4e6727973e3743a59eced9bae334dc472025-08-20T02:50:40ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-04-0118466367110.18240/ijo.2025.04.1320250413Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathyZi-Jia Liu0Xian Xu1Ya-Nan Lyu2Dong-Li Li3Hao Zhou4Yuan-Yuan Gong5Yuan-Yuan Gong. Shanghai Engineering Center for Visual Science and Photomedicine, No.100, Haining Road, Hongkou District, Shanghai 200080, China. gyydr@126.comDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 200080, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 200080, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 200080, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 200080, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 200080, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, ChinaAIM: To evaluate the efficacy and safety of intravitreal low-dose (1 mg) triamcinolone acetonide (TA) in Chinese acute nonarteritic anterior ischemic optic neuropathy (NAION) patients. METHODS: Twenty-eight eyes of 28 patients with acute NAION (<30d of visual acuity loss) were enrolled and given intravitreal TA (IVTA) once. Visual field (VF), best corrected visual acuity (BCVA), retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, radial peripapillary capillary (RPC) density, and intraocular pressure (IOP) were evaluated at baseline and 7d, 1, 3, and 6mo after IVTA. RESULTS: VF and BCVA were significant improved during the follow-up according to the mean deviation (MD), visual field index (VFI), and Early Treatment Diabetic Retinopathy Study (ETDRS) scores (all P<0.001). There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset. The RNFL thickness, GCC thickness and RPC density were significantly decreased (all P<0.001). Temporary ocular hypertension was present in five eyes. CONCLUSION: Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage. However, optic nerve atrophy still existed.http://ies.ijo.cn/en_publish/2025/4/20250413.pdfnonarteritic anterior ischemic optic neuropathytriamcinolone acetonideintravitreal injectionsvisual fieldvisual acuity |
| spellingShingle | Zi-Jia Liu Xian Xu Ya-Nan Lyu Dong-Li Li Hao Zhou Yuan-Yuan Gong Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy International Journal of Ophthalmology nonarteritic anterior ischemic optic neuropathy triamcinolone acetonide intravitreal injections visual field visual acuity |
| title | Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy |
| title_full | Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy |
| title_fullStr | Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy |
| title_full_unstemmed | Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy |
| title_short | Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy |
| title_sort | intravitreal low dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy |
| topic | nonarteritic anterior ischemic optic neuropathy triamcinolone acetonide intravitreal injections visual field visual acuity |
| url | http://ies.ijo.cn/en_publish/2025/4/20250413.pdf |
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