The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Abstract The auditory circuit primarily consists of peripheral auditory organs and auditory neural pathways. Hearing loss (HL), as reported by the World Health Organization, affects more than one in eight people worldwide, often leading to severe dysfunction that detrimentally impacts patients'...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410494 |
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| author | Zhe Li Ying Zhang Zhenyu Xiao Jieyu Qi |
| author_facet | Zhe Li Ying Zhang Zhenyu Xiao Jieyu Qi |
| author_sort | Zhe Li |
| collection | DOAJ |
| description | Abstract The auditory circuit primarily consists of peripheral auditory organs and auditory neural pathways. Hearing loss (HL), as reported by the World Health Organization, affects more than one in eight people worldwide, often leading to severe dysfunction that detrimentally impacts patients' quality of life. Therefore, auditory reconstruction has emerged as a persistent research hotspot and challenge within the biomedical field. Traditional methods for auditory reconstruction, such as drug therapy, hearing aids, cochlear implants (CIs), and so on. To a certain extent, it can help patients with HL improve their hearing status. However, they possess inherent advantages and limitations. Recent advancements in biomaterials, gene editing, stem cells, organoids, and other technologies have ushered in new prospects for the treatment of hearing impairment. This review focuses on the potential of innovative technologies in biomaterials, stem cells, and gene editing in hearing recovery. It reviews the current research status of inner ear hair cell (HC) regeneration, spiral ganglion neuron (SGN) regeneration, and inner ear organoid construction in the auditory loop. Furthermore, the review discusses the challenges associated with these approaches and explores potential future directions, aiming to furnish a comprehensive reference for both research and clinical applications in the domain of peripheral auditory restoration. |
| format | Article |
| id | doaj-art-4e6256a152e140ca90094dd58cff3341 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-4e6256a152e140ca90094dd58cff33412025-08-20T03:40:00ZengWileyAdvanced Science2198-38442025-08-011229n/an/a10.1002/advs.202410494The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future ChallengesZhe Li0Ying Zhang1Zhenyu Xiao2Jieyu Qi3School of Life Beijing Institute of Technology Beijing 100081 ChinaSchool of Life Beijing Institute of Technology Beijing 100081 ChinaSchool of Life Beijing Institute of Technology Beijing 100081 ChinaSchool of Life Beijing Institute of Technology Beijing 100081 ChinaAbstract The auditory circuit primarily consists of peripheral auditory organs and auditory neural pathways. Hearing loss (HL), as reported by the World Health Organization, affects more than one in eight people worldwide, often leading to severe dysfunction that detrimentally impacts patients' quality of life. Therefore, auditory reconstruction has emerged as a persistent research hotspot and challenge within the biomedical field. Traditional methods for auditory reconstruction, such as drug therapy, hearing aids, cochlear implants (CIs), and so on. To a certain extent, it can help patients with HL improve their hearing status. However, they possess inherent advantages and limitations. Recent advancements in biomaterials, gene editing, stem cells, organoids, and other technologies have ushered in new prospects for the treatment of hearing impairment. This review focuses on the potential of innovative technologies in biomaterials, stem cells, and gene editing in hearing recovery. It reviews the current research status of inner ear hair cell (HC) regeneration, spiral ganglion neuron (SGN) regeneration, and inner ear organoid construction in the auditory loop. Furthermore, the review discusses the challenges associated with these approaches and explores potential future directions, aiming to furnish a comprehensive reference for both research and clinical applications in the domain of peripheral auditory restoration.https://doi.org/10.1002/advs.202410494biomaterialshearing lossperipheral auditory circuitreconstructionstem cell |
| spellingShingle | Zhe Li Ying Zhang Zhenyu Xiao Jieyu Qi The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges Advanced Science biomaterials hearing loss peripheral auditory circuit reconstruction stem cell |
| title | The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges |
| title_full | The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges |
| title_fullStr | The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges |
| title_full_unstemmed | The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges |
| title_short | The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges |
| title_sort | reconstruction of peripheral auditory circuit recent advances and future challenges |
| topic | biomaterials hearing loss peripheral auditory circuit reconstruction stem cell |
| url | https://doi.org/10.1002/advs.202410494 |
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