Sleep discrepancy and brain glucose metabolism in community-dwelling older adults
Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose m...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Aging Brain |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958924000264 |
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| author | Nadia Soh Michael Weinborn James D. Doecke Rodrigo Canovas Vincent Doré Ying Xia Jurgen Fripp Kevin Taddei Romola S. Bucks Hamid R. Sohrabi Ralph N. Martins Melissa Ree Stephanie R. Rainey-Smith |
| author_facet | Nadia Soh Michael Weinborn James D. Doecke Rodrigo Canovas Vincent Doré Ying Xia Jurgen Fripp Kevin Taddei Romola S. Bucks Hamid R. Sohrabi Ralph N. Martins Melissa Ree Stephanie R. Rainey-Smith |
| author_sort | Nadia Soh |
| collection | DOAJ |
| description | Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose metabolism (assessed globally and regionally via positron emission tomography), and to evaluate the contribution of insomnia severity and depressive symptoms to any associations. Using data from cognitively unimpaired community-dwelling older adults (N = 68), cluster analysis was used to characterise sleep discrepancy (for total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)), and logistic regression was used to explore sleep discrepancy’s associations with brain glucose metabolism, while controlling for insomnia severity and depressive symptoms. Lower glucose metabolism across multiple brain regions was associated with negative discrepancy for WASO and SE, and positive discrepancy for WASO only (large effect sizes; β ≥ 0.5). Higher glucose metabolism in the superior parietal and posterior cingulate regions was associated with negative discrepancy for TST (large effect sizes; β ≥ 0.5). These associations remained when controlling for insomnia severity and depressive symptoms, suggesting a unique role of sleep discrepancy as a potential early behavioural marker of brain health. |
| format | Article |
| id | doaj-art-4e5fde4bd7b44eb38869fd9ba9fec741 |
| institution | OA Journals |
| issn | 2589-9589 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj-art-4e5fde4bd7b44eb38869fd9ba9fec7412025-08-20T02:21:07ZengElsevierAging Brain2589-95892024-01-01610013010.1016/j.nbas.2024.100130Sleep discrepancy and brain glucose metabolism in community-dwelling older adultsNadia Soh0Michael Weinborn1James D. Doecke2Rodrigo Canovas3Vincent Doré4Ying Xia5Jurgen Fripp6Kevin Taddei7Romola S. Bucks8Hamid R. Sohrabi9Ralph N. Martins10Melissa Ree11Stephanie R. Rainey-Smith12School of Psychological Science, University of Western Australia, Crawley, Western Australia, AustraliaSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia; Australian Alzheimer’s Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, AustraliaAustralian E-Health Research Centre, CSIRO, Herston, Queensland, AustraliaAustralian E-Health Research Centre, CSIRO, Melbourne, Victoria, AustraliaAustralian E-Health Research Centre, CSIRO, Melbourne, Victoria, Australia; Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, AustraliaAustralian E-Health Research Centre, CSIRO, Herston, Queensland, AustraliaAustralian E-Health Research Centre, CSIRO, Herston, Queensland, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, AustraliaSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia; School of Population and Global Health, University of Western Australia, Crawley, Western Australia, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; Department of Biomedical Sciences, Macquarie University, New South Wales, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Department of Biomedical Sciences, Macquarie University, New South Wales, AustraliaSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, AustraliaSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia; Australian Alzheimer’s Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; Corresponding author at: Centre for Healthy Ageing, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, Western Australia 6150, Australia.Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose metabolism (assessed globally and regionally via positron emission tomography), and to evaluate the contribution of insomnia severity and depressive symptoms to any associations. Using data from cognitively unimpaired community-dwelling older adults (N = 68), cluster analysis was used to characterise sleep discrepancy (for total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)), and logistic regression was used to explore sleep discrepancy’s associations with brain glucose metabolism, while controlling for insomnia severity and depressive symptoms. Lower glucose metabolism across multiple brain regions was associated with negative discrepancy for WASO and SE, and positive discrepancy for WASO only (large effect sizes; β ≥ 0.5). Higher glucose metabolism in the superior parietal and posterior cingulate regions was associated with negative discrepancy for TST (large effect sizes; β ≥ 0.5). These associations remained when controlling for insomnia severity and depressive symptoms, suggesting a unique role of sleep discrepancy as a potential early behavioural marker of brain health.http://www.sciencedirect.com/science/article/pii/S2589958924000264SleepSleep DiscrepancyBrain HealthGlucose MetabolismAlzheimer’s diseaseFDG-PET |
| spellingShingle | Nadia Soh Michael Weinborn James D. Doecke Rodrigo Canovas Vincent Doré Ying Xia Jurgen Fripp Kevin Taddei Romola S. Bucks Hamid R. Sohrabi Ralph N. Martins Melissa Ree Stephanie R. Rainey-Smith Sleep discrepancy and brain glucose metabolism in community-dwelling older adults Aging Brain Sleep Sleep Discrepancy Brain Health Glucose Metabolism Alzheimer’s disease FDG-PET |
| title | Sleep discrepancy and brain glucose metabolism in community-dwelling older adults |
| title_full | Sleep discrepancy and brain glucose metabolism in community-dwelling older adults |
| title_fullStr | Sleep discrepancy and brain glucose metabolism in community-dwelling older adults |
| title_full_unstemmed | Sleep discrepancy and brain glucose metabolism in community-dwelling older adults |
| title_short | Sleep discrepancy and brain glucose metabolism in community-dwelling older adults |
| title_sort | sleep discrepancy and brain glucose metabolism in community dwelling older adults |
| topic | Sleep Sleep Discrepancy Brain Health Glucose Metabolism Alzheimer’s disease FDG-PET |
| url | http://www.sciencedirect.com/science/article/pii/S2589958924000264 |
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