Brain glutamate and gamma-aminobutyric acid levels across COVID-19 lockdowns in patients with recurrent major depressive disorder and healthy individuals

Brain glutamate and gamma-aminobutyric acid levels across COVID-19 lockdowns in patients with recurrent major depressive disorder and healthy individuals

Abstract The coronavirus disease 2019 (COVID-19) led to substantial social restriction measures. Social isolation has been demonstrated to promote psychiatric symptoms and to dysregulate gamma-aminobutyric acid (GABA) and glutamate levels. The aim of this investigation was to observe brain GABA and...

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Main Authors: Valentin Popper, Benjamin Spurny-Dworak, Jakob Unterholzner, Murray Reed, Theresa Wechsler, Alexander Kautzky, Peter Stöhrmann, Manfred Klöbl, Andreas Mühlberger, Richard Frey, Dan Rujescu, Rupert Lanzenberger, Thomas Vanicek
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-05734-2
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