Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therap...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/874836 |
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| _version_ | 1832564747947474944 |
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| author | Glen J. Weiss Agnes K. Liman Jeffrey Allen Philip Y. Cheung Rajesh N. Kukunoor |
| author_facet | Glen J. Weiss Agnes K. Liman Jeffrey Allen Philip Y. Cheung Rajesh N. Kukunoor |
| author_sort | Glen J. Weiss |
| collection | DOAJ |
| description | We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity. |
| format | Article |
| id | doaj-art-4e59eb5c02334094a268571cd57b226b |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-4e59eb5c02334094a268571cd57b226b2025-02-03T01:10:16ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/874836874836Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 DeletionGlen J. Weiss0Agnes K. Liman1Jeffrey Allen2Philip Y. Cheung3Rajesh N. Kukunoor4Cancer Treatment Centers of America, Goodyear, AZ 85338, USAVeterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15206, USAHumboldt Medical Specialists, Eureka, CA 95501, USAThe Translational Genomics Research Institute, Phoenix, AZ 85004, USAIronwood Cancer and Research Centers, Phoenix, AZ 85028, USAWe describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity.http://dx.doi.org/10.1155/2013/874836 |
| spellingShingle | Glen J. Weiss Agnes K. Liman Jeffrey Allen Philip Y. Cheung Rajesh N. Kukunoor Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion Case Reports in Medicine |
| title | Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion |
| title_full | Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion |
| title_fullStr | Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion |
| title_full_unstemmed | Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion |
| title_short | Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion |
| title_sort | squamous cell carcinoma of the lung with metastasis to the gi tract associated with egfr exon 19 deletion |
| url | http://dx.doi.org/10.1155/2013/874836 |
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