The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s
The human C-MYC promoter and telomere G4 DNA structures were widely recognized as promising targets for cancer therapy. Nevertheless, the effectiveness of the traditional small-molecule fluorescent probe targeting G4 was hindered by limitations in single function and low selectivity, and progress in...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221171562400701X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583085595557888 |
|---|---|
| author | Lilin Gan Wenzheng Luo Qian Cheng Shanke Wan Min Wu Mingqi Wang Enming Luo Xianjin Luo Shuo Li |
| author_facet | Lilin Gan Wenzheng Luo Qian Cheng Shanke Wan Min Wu Mingqi Wang Enming Luo Xianjin Luo Shuo Li |
| author_sort | Lilin Gan |
| collection | DOAJ |
| description | The human C-MYC promoter and telomere G4 DNA structures were widely recognized as promising targets for cancer therapy. Nevertheless, the effectiveness of the traditional small-molecule fluorescent probe targeting G4 was hindered by limitations in single function and low selectivity, and progress in anti-tumor research was impeded. In this study, a novel naphthalimide probe（AI7）was synthesized and reported for hybrid G4 structures targeting, and 3–10 times fluorescence intensity was increased by the interaction with hybrid G4 structures. Meanwhile, the fluorescence intensity was significantly enhanced when hybrid G4 structures within the cell nucleus with AI7 were bound. S-phase DNA extracts from normal and tumor cells, there were obvious differences in fluorescence intensities when conjugated with AI7, which could distinguish each other. Herein, AI7 also showed potential anti-tumor activity and good biological compatibility. |
| format | Article |
| id | doaj-art-4e5821a4b01e43fbad6cf3d1e722d2a7 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-4e5821a4b01e43fbad6cf3d1e722d2a72025-01-29T05:00:53ZengElsevierResults in Chemistry2211-71562025-01-0113102005The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4sLilin Gan0Wenzheng Luo1Qian Cheng2Shanke Wan3Min Wu4Mingqi Wang5Enming Luo6Xianjin Luo7Shuo Li8College of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, ChinaDepartment of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaSchool of Pharmacy, Jiangsu University, Zhenjiang 212013, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China; Corresponding author.The human C-MYC promoter and telomere G4 DNA structures were widely recognized as promising targets for cancer therapy. Nevertheless, the effectiveness of the traditional small-molecule fluorescent probe targeting G4 was hindered by limitations in single function and low selectivity, and progress in anti-tumor research was impeded. In this study, a novel naphthalimide probe（AI7）was synthesized and reported for hybrid G4 structures targeting, and 3–10 times fluorescence intensity was increased by the interaction with hybrid G4 structures. Meanwhile, the fluorescence intensity was significantly enhanced when hybrid G4 structures within the cell nucleus with AI7 were bound. S-phase DNA extracts from normal and tumor cells, there were obvious differences in fluorescence intensities when conjugated with AI7, which could distinguish each other. Herein, AI7 also showed potential anti-tumor activity and good biological compatibility.http://www.sciencedirect.com/science/article/pii/S221171562400701XG4 DNAS phase DNAAnti-tumorFluorescence imaging |
| spellingShingle | Lilin Gan Wenzheng Luo Qian Cheng Shanke Wan Min Wu Mingqi Wang Enming Luo Xianjin Luo Shuo Li The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s Results in Chemistry G4 DNA S phase DNA Anti-tumor Fluorescence imaging |
| title | The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s |
| title_full | The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s |
| title_fullStr | The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s |
| title_full_unstemmed | The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s |
| title_short | The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s |
| title_sort | synthesis and research of the naphthalimide g quadruplex probe targeting hybrid g4s |
| topic | G4 DNA S phase DNA Anti-tumor Fluorescence imaging |
| url | http://www.sciencedirect.com/science/article/pii/S221171562400701X |
| work_keys_str_mv | AT lilingan thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT wenzhengluo thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT qiancheng thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT shankewan thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT minwu thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT mingqiwang thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT enmingluo thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT xianjinluo thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT shuoli thesynthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT lilingan synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT wenzhengluo synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT qiancheng synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT shankewan synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT minwu synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT mingqiwang synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT enmingluo synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT xianjinluo synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s AT shuoli synthesisandresearchofthenaphthalimidegquadruplexprobetargetinghybridg4s |