Untangling a case of dapsone-induced acute liver injury
Dapsone hypersensitivity syndrome, although rare, may manifest with fever, rash, and multi-organ failure, mimicking other common diseases. This case study involves a 9-year-old female patient presenting with fever and acute liver injury, in which the intake of dapsone was not revealed until much lat...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_885_24 |
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| author | V Meghana Divya Ravindran Umapathy Pasupathy |
| author_facet | V Meghana Divya Ravindran Umapathy Pasupathy |
| author_sort | V Meghana |
| collection | DOAJ |
| description | Dapsone hypersensitivity syndrome, although rare, may manifest with fever, rash, and multi-organ failure, mimicking other common diseases. This case study involves a 9-year-old female patient presenting with fever and acute liver injury, in which the intake of dapsone was not revealed until much later. We discuss how the diagnosis was made and the successful outcome following prompt treatment. A high index of suspicion and vigilant history-taking, along with a detailed past treatment history, can provide early clues in reaching a diagnosis. Early intervention with systemic corticosteroids improves the outcome of dapsone hypersensitivity syndrome and can prevent mortality. |
| format | Article |
| id | doaj-art-4e5513836faf446fbdeb2234ceaee074 |
| institution | Kabale University |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-4e5513836faf446fbdeb2234ceaee0742025-02-11T14:06:46ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352025-01-0114149850110.4103/jfmpc.jfmpc_885_24Untangling a case of dapsone-induced acute liver injuryV MeghanaDivya RavindranUmapathy PasupathyDapsone hypersensitivity syndrome, although rare, may manifest with fever, rash, and multi-organ failure, mimicking other common diseases. This case study involves a 9-year-old female patient presenting with fever and acute liver injury, in which the intake of dapsone was not revealed until much later. We discuss how the diagnosis was made and the successful outcome following prompt treatment. A high index of suspicion and vigilant history-taking, along with a detailed past treatment history, can provide early clues in reaching a diagnosis. Early intervention with systemic corticosteroids improves the outcome of dapsone hypersensitivity syndrome and can prevent mortality.https://journals.lww.com/10.4103/jfmpc.jfmpc_885_24dapsone hypersensitivity syndromedrug-induced liver injurypediatric drug hypersensitivity |
| spellingShingle | V Meghana Divya Ravindran Umapathy Pasupathy Untangling a case of dapsone-induced acute liver injury Journal of Family Medicine and Primary Care dapsone hypersensitivity syndrome drug-induced liver injury pediatric drug hypersensitivity |
| title | Untangling a case of dapsone-induced acute liver injury |
| title_full | Untangling a case of dapsone-induced acute liver injury |
| title_fullStr | Untangling a case of dapsone-induced acute liver injury |
| title_full_unstemmed | Untangling a case of dapsone-induced acute liver injury |
| title_short | Untangling a case of dapsone-induced acute liver injury |
| title_sort | untangling a case of dapsone induced acute liver injury |
| topic | dapsone hypersensitivity syndrome drug-induced liver injury pediatric drug hypersensitivity |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_885_24 |
| work_keys_str_mv | AT vmeghana untanglingacaseofdapsoneinducedacuteliverinjury AT divyaravindran untanglingacaseofdapsoneinducedacuteliverinjury AT umapathypasupathy untanglingacaseofdapsoneinducedacuteliverinjury |