Overcoming scarring in the urethra: Challenges for tissue engineering
Urethral stricture disease is increasingly common occurring in about 1% of males over the age of 55. The stricture tissue is rich in myofibroblasts and multi-nucleated giant cells which are thought to be related to stricture formation and collagen synthesis. An increase in collagen is associated wit...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | Asian Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388218300109 |
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| author | Abdulmuttalip Simsek Reem Aldamanhori Christopher R. Chapple Sheila MacNeil |
| author_facet | Abdulmuttalip Simsek Reem Aldamanhori Christopher R. Chapple Sheila MacNeil |
| author_sort | Abdulmuttalip Simsek |
| collection | DOAJ |
| description | Urethral stricture disease is increasingly common occurring in about 1% of males over the age of 55. The stricture tissue is rich in myofibroblasts and multi-nucleated giant cells which are thought to be related to stricture formation and collagen synthesis. An increase in collagen is associated with the loss of the normal vasculature of the normal urethra. The actual incidence differs based on worldwide populations, geography, and income. The stricture aetiology, location, length and patient's age and comorbidity are important in deciding the course of treatment. In this review we aim to summarise the existing knowledge of the aetiology of urethral strictures, review current treatment regimens, and present the challenges of using tissue-engineered buccal mucosa (TEBM) to repair scarring of the urethra. In asking this question we are also mindful that recurrent fibrosis occurs in other tissues—how can we learn from these other pathologies? Keywords: Urethral strictures, Fibrosis, Tissue-engineered buccal mucosa, Augmentation urethroplasty |
| format | Article |
| id | doaj-art-4e5490e105ec40e58a50db258067e78e |
| institution | OA Journals |
| issn | 2214-3882 |
| language | English |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-4e5490e105ec40e58a50db258067e78e2025-08-20T01:55:52ZengElsevierAsian Journal of Urology2214-38822018-04-0152697710.1016/j.ajur.2018.02.002Overcoming scarring in the urethra: Challenges for tissue engineeringAbdulmuttalip Simsek0Reem Aldamanhori1Christopher R. Chapple2Sheila MacNeil3Department of Urology, Royal Hallamshire Hospital, Sheffield, UK; Department of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UKDepartment of Urology, Royal Hallamshire Hospital, Sheffield, UKDepartment of Urology, Royal Hallamshire Hospital, Sheffield, UKDepartment of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UK; Corresponding author.Urethral stricture disease is increasingly common occurring in about 1% of males over the age of 55. The stricture tissue is rich in myofibroblasts and multi-nucleated giant cells which are thought to be related to stricture formation and collagen synthesis. An increase in collagen is associated with the loss of the normal vasculature of the normal urethra. The actual incidence differs based on worldwide populations, geography, and income. The stricture aetiology, location, length and patient's age and comorbidity are important in deciding the course of treatment. In this review we aim to summarise the existing knowledge of the aetiology of urethral strictures, review current treatment regimens, and present the challenges of using tissue-engineered buccal mucosa (TEBM) to repair scarring of the urethra. In asking this question we are also mindful that recurrent fibrosis occurs in other tissues—how can we learn from these other pathologies? Keywords: Urethral strictures, Fibrosis, Tissue-engineered buccal mucosa, Augmentation urethroplastyhttp://www.sciencedirect.com/science/article/pii/S2214388218300109 |
| spellingShingle | Abdulmuttalip Simsek Reem Aldamanhori Christopher R. Chapple Sheila MacNeil Overcoming scarring in the urethra: Challenges for tissue engineering Asian Journal of Urology |
| title | Overcoming scarring in the urethra: Challenges for tissue engineering |
| title_full | Overcoming scarring in the urethra: Challenges for tissue engineering |
| title_fullStr | Overcoming scarring in the urethra: Challenges for tissue engineering |
| title_full_unstemmed | Overcoming scarring in the urethra: Challenges for tissue engineering |
| title_short | Overcoming scarring in the urethra: Challenges for tissue engineering |
| title_sort | overcoming scarring in the urethra challenges for tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2214388218300109 |
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