Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report
An elevation in serum immunoglobulin (Ig) G4 concentrations at only one time point is not a definitive diagnostic marker for IgG4-related diseases. We report two cases of pulmonary paragonimiasis with elevated serum IgG4 concentrations. Patient 1 was a woman in her late 40s with cough and dyspnea fo...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605251317980 |
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| author | Pengyan Yin Miaohui Duan Lingyao Deng Tianli Li Xuan Huang Raohong Fang Hailong Li Binliang Bai |
| author_facet | Pengyan Yin Miaohui Duan Lingyao Deng Tianli Li Xuan Huang Raohong Fang Hailong Li Binliang Bai |
| author_sort | Pengyan Yin |
| collection | DOAJ |
| description | An elevation in serum immunoglobulin (Ig) G4 concentrations at only one time point is not a definitive diagnostic marker for IgG4-related diseases. We report two cases of pulmonary paragonimiasis with elevated serum IgG4 concentrations. Patient 1 was a woman in her late 40s with cough and dyspnea for 1 week. Patient 2 was a woman in her late 60s with a cough, bloody sputum, chest pain, and wheezing for over 1 month. Patient 1 had eosinophilia, high IgE, IgG, and IgG4 concentrations, right pleural effusion, and lung lesions, resembling tuberculosis. Patient 2 had cavitary lung lesions, pleural involvement, and eosinophilia, and high IgE, IgG, and IgG4 concentrations, with a history of eating raw river crabs. Both patients tested positive for Paragonimus antibodies. Patient 1 received 2 months of anti-parasitic treatment, while Patient 2 had 1 week of treatment. Patient 2 showed improvement and was discharged with normalized Ig concentrations. Increased serum IgG4 concentrations, in conjunction with elevated concentrations of IgG, IgE and eosinophil counts, and a history of travel or residence in areas endemic for paragonimiasis, can be used to distinguish pulmonary paragonimiasis from other etiologies of pneumonia. |
| format | Article |
| id | doaj-art-4e52fd55f54c4520a712763b72176b98 |
| institution | DOAJ |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-4e52fd55f54c4520a712763b72176b982025-08-20T02:45:02ZengSAGE PublishingJournal of International Medical Research1473-23002025-02-015310.1177/03000605251317980Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case reportPengyan YinMiaohui DuanLingyao DengTianli LiXuan HuangRaohong FangHailong LiBinliang BaiAn elevation in serum immunoglobulin (Ig) G4 concentrations at only one time point is not a definitive diagnostic marker for IgG4-related diseases. We report two cases of pulmonary paragonimiasis with elevated serum IgG4 concentrations. Patient 1 was a woman in her late 40s with cough and dyspnea for 1 week. Patient 2 was a woman in her late 60s with a cough, bloody sputum, chest pain, and wheezing for over 1 month. Patient 1 had eosinophilia, high IgE, IgG, and IgG4 concentrations, right pleural effusion, and lung lesions, resembling tuberculosis. Patient 2 had cavitary lung lesions, pleural involvement, and eosinophilia, and high IgE, IgG, and IgG4 concentrations, with a history of eating raw river crabs. Both patients tested positive for Paragonimus antibodies. Patient 1 received 2 months of anti-parasitic treatment, while Patient 2 had 1 week of treatment. Patient 2 showed improvement and was discharged with normalized Ig concentrations. Increased serum IgG4 concentrations, in conjunction with elevated concentrations of IgG, IgE and eosinophil counts, and a history of travel or residence in areas endemic for paragonimiasis, can be used to distinguish pulmonary paragonimiasis from other etiologies of pneumonia.https://doi.org/10.1177/03000605251317980 |
| spellingShingle | Pengyan Yin Miaohui Duan Lingyao Deng Tianli Li Xuan Huang Raohong Fang Hailong Li Binliang Bai Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report Journal of International Medical Research |
| title | Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report |
| title_full | Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report |
| title_fullStr | Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report |
| title_full_unstemmed | Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report |
| title_short | Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report |
| title_sort | initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin g4 concentrations a case report |
| url | https://doi.org/10.1177/03000605251317980 |
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