Clinical Indications and Abuse of Corticosteroids: A Narrative Review
Corticosteroids are lifesaving drugs; however, their abuse has been noted in general population. The objectives of the review were to highlight the adverse effects after prolonged use and abuse of corticosteroids. The review covers the period of 2000-2023. After extracting information from over 76...
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| Format: | Article |
| Language: | English |
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Liaquat National Hospital and Medical College
2025-02-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/b2247ae0-9c67-4013-b6c9-ac2dcdd414d5.pdf |
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| _version_ | 1849722236506734592 |
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| author | Sheikh Abdul Khaliq Sabeen Naz Faryal Farid Anab Fatima |
| author_facet | Sheikh Abdul Khaliq Sabeen Naz Faryal Farid Anab Fatima |
| author_sort | Sheikh Abdul Khaliq |
| collection | DOAJ |
| description | Corticosteroids are lifesaving drugs; however, their abuse has been noted in general population. The objectives of the review were
to highlight the adverse effects after prolonged use and abuse of corticosteroids. The review covers the period of 2000-2023. After
extracting information from over 76 articles and evaluating their quality, data was presented as PRISMA diagram. The main adverse
effects appear after abuse or prolonged use of corticosteroids are immune suppression, osteoporosis, weight gain, stunted growth
in children, glucose intolerance, hypertrichosis, acne, telangiectiasis, hypertension, mood disorder, rosacea, peri-oral dermatitis,
fibrosis of renal, cardiac and vascular cells, hormonal-disturbances, cataract, glaucoma and prolong use in COVID-19 patients
enhanced the mortality. Mostly corticosteroids were used as a fairness cream for a long time without medical supervision. Despite
corticosteroids’ clinical benefits, their abuse as fairness cream is not justified. Therefore, the general public has to be educated
about the adverse effects associated with corticosteroid prolongation and abuse. A coordinated strategy is required among patients,
physicians and pharmacists to stop the mistreatment of topical corticosteroids. |
| format | Article |
| id | doaj-art-4e4efcab94714c14baa840738de917f0 |
| institution | DOAJ |
| issn | 2707-3521 2708-9134 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj-art-4e4efcab94714c14baa840738de917f02025-08-20T03:11:24ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342025-02-0171596410.37184/lnjpc.2707-3521.7.1Clinical Indications and Abuse of Corticosteroids: A Narrative ReviewSheikh Abdul Khaliq0Sabeen Naz1Faryal Farid2Anab Fatima3Department of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Karachi, PakistanDepartment of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan Dow College of Pharmacy, Dow University of Health Sciences, Karachi, PakistanCorticosteroids are lifesaving drugs; however, their abuse has been noted in general population. The objectives of the review were to highlight the adverse effects after prolonged use and abuse of corticosteroids. The review covers the period of 2000-2023. After extracting information from over 76 articles and evaluating their quality, data was presented as PRISMA diagram. The main adverse effects appear after abuse or prolonged use of corticosteroids are immune suppression, osteoporosis, weight gain, stunted growth in children, glucose intolerance, hypertrichosis, acne, telangiectiasis, hypertension, mood disorder, rosacea, peri-oral dermatitis, fibrosis of renal, cardiac and vascular cells, hormonal-disturbances, cataract, glaucoma and prolong use in COVID-19 patients enhanced the mortality. Mostly corticosteroids were used as a fairness cream for a long time without medical supervision. Despite corticosteroids’ clinical benefits, their abuse as fairness cream is not justified. Therefore, the general public has to be educated about the adverse effects associated with corticosteroid prolongation and abuse. A coordinated strategy is required among patients, physicians and pharmacists to stop the mistreatment of topical corticosteroids.https://journals.lnh.edu.pk/lnjpc/pdf/b2247ae0-9c67-4013-b6c9-ac2dcdd414d5.pdfcorticosteroidsabuseadverse effectsawarenesslegitimate indication. |
| spellingShingle | Sheikh Abdul Khaliq Sabeen Naz Faryal Farid Anab Fatima Clinical Indications and Abuse of Corticosteroids: A Narrative Review Liaquat National Journal of Primary Care corticosteroids abuse adverse effects awareness legitimate indication. |
| title | Clinical Indications and Abuse of Corticosteroids: A Narrative Review |
| title_full | Clinical Indications and Abuse of Corticosteroids: A Narrative Review |
| title_fullStr | Clinical Indications and Abuse of Corticosteroids: A Narrative Review |
| title_full_unstemmed | Clinical Indications and Abuse of Corticosteroids: A Narrative Review |
| title_short | Clinical Indications and Abuse of Corticosteroids: A Narrative Review |
| title_sort | clinical indications and abuse of corticosteroids a narrative review |
| topic | corticosteroids abuse adverse effects awareness legitimate indication. |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/b2247ae0-9c67-4013-b6c9-ac2dcdd414d5.pdf |
| work_keys_str_mv | AT sheikhabdulkhaliq clinicalindicationsandabuseofcorticosteroidsanarrativereview AT sabeennaz clinicalindicationsandabuseofcorticosteroidsanarrativereview AT faryalfarid clinicalindicationsandabuseofcorticosteroidsanarrativereview AT anabfatima clinicalindicationsandabuseofcorticosteroidsanarrativereview |