Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia
Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significa...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Journal of Pharmaceutical Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177925000188 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849341991191576576 |
|---|---|
| author | Chenqi Chang Chang Lu Yu Zheng Lili Lin XiuZhen Chen Linwei Chen Zhipeng Chen Rui Chen |
| author_facet | Chenqi Chang Chang Lu Yu Zheng Lili Lin XiuZhen Chen Linwei Chen Zhipeng Chen Rui Chen |
| author_sort | Chenqi Chang |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action. Nonetheless, the clinical application of BA is constrained by its low solubility and bioavailability. In this study, we prepared BA nanodrugs (BA NDs) with enhanced water solubility utilizing the supramolecular self-assembled strategy, and we further conducted a comparative analysis of this pharmacological activity between free drugs and NDs of BA. Both in vitro and in vivo results demonstrated that BA NDs significantly enhanced the dual effects of viral inhibition and inflammation relief compared to free BA, attributed to prolonged lung retention, improved cellular uptake, and increased targeting affinity. Our study confirms that the nanosizing strategy, a straightforward approach to enhance drug solubility, can also increase biological activity compared to free drugs with the same content, thereby providing a potential ND for RSV treatment. This correlation analysis between the existing forms of drugs and their biological activity offers a novel perspective for research on the active ingredients of traditional Chinese medicine. |
| format | Article |
| id | doaj-art-4e4b2ff53f5946cab5e3bf27df0cb03c |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-4e4b2ff53f5946cab5e3bf27df0cb03c2025-08-20T03:43:31ZengElsevierJournal of Pharmaceutical Analysis2095-17792025-07-0115710120110.1016/j.jpha.2025.101201Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumoniaChenqi Chang0Chang Lu1Yu Zheng2Lili Lin3XiuZhen Chen4Linwei Chen5Zhipeng Chen6Rui Chen7College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Department of Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, Jiangsu, 225300, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Department of Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, Jiangsu, 225300, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaJiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Medical Metabolomics Center, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaClinical Research Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, ChinaDepartment of Pharmacy, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, Jiangsu, 225300, China; Corresponding author.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Corresponding author.College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Corresponding author.Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action. Nonetheless, the clinical application of BA is constrained by its low solubility and bioavailability. In this study, we prepared BA nanodrugs (BA NDs) with enhanced water solubility utilizing the supramolecular self-assembled strategy, and we further conducted a comparative analysis of this pharmacological activity between free drugs and NDs of BA. Both in vitro and in vivo results demonstrated that BA NDs significantly enhanced the dual effects of viral inhibition and inflammation relief compared to free BA, attributed to prolonged lung retention, improved cellular uptake, and increased targeting affinity. Our study confirms that the nanosizing strategy, a straightforward approach to enhance drug solubility, can also increase biological activity compared to free drugs with the same content, thereby providing a potential ND for RSV treatment. This correlation analysis between the existing forms of drugs and their biological activity offers a novel perspective for research on the active ingredients of traditional Chinese medicine.http://www.sciencedirect.com/science/article/pii/S2095177925000188Respiratory syncytial virusBaicalinNanodrugsBiological activity analysisAntiviralAnti-inflammatory |
| spellingShingle | Chenqi Chang Chang Lu Yu Zheng Lili Lin XiuZhen Chen Linwei Chen Zhipeng Chen Rui Chen Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia Journal of Pharmaceutical Analysis Respiratory syncytial virus Baicalin Nanodrugs Biological activity analysis Antiviral Anti-inflammatory |
| title | Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia |
| title_full | Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia |
| title_fullStr | Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia |
| title_full_unstemmed | Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia |
| title_short | Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia |
| title_sort | biological activity analysis of baicalin nanodrugs nanosizing enhances antiviral and anti inflammatory effects in the treatment of viral pneumonia |
| topic | Respiratory syncytial virus Baicalin Nanodrugs Biological activity analysis Antiviral Anti-inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S2095177925000188 |
| work_keys_str_mv | AT chenqichang biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT changlu biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT yuzheng biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT lililin biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT xiuzhenchen biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT linweichen biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT zhipengchen biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia AT ruichen biologicalactivityanalysisofbaicalinnanodrugsnanosizingenhancesantiviralandantiinflammatoryeffectsinthetreatmentofviralpneumonia |