Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose
The present study is focused on investigation of the health protective effect of yellow rice wine (YRW) in mice and the potential underlying mechanism. Symptoms of aging were induced in mice by using D-galactose (D-gal), and different doses of YRW (4, 8, and 12 mL/kg BW) were orally administrated to...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2020-06-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019301703 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557575124549632 |
|---|---|
| author | Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao |
| author_facet | Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao |
| author_sort | Rong Liu |
| collection | DOAJ |
| description | The present study is focused on investigation of the health protective effect of yellow rice wine (YRW) in mice and the potential underlying mechanism. Symptoms of aging were induced in mice by using D-galactose (D-gal), and different doses of YRW (4, 8, and 12 mL/kg BW) were orally administrated to D-gal-treated mice for a period of six weeks. The in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and liver. Furthermore, a forced swim test showed that moderate intake of YRW (8 mL/kg BW) significantly decreased the duration of immobility, reduced the blood content of urea nitrogen and lactic acid, and increased hepatic glycogen storage. Besides, results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3. The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action. |
| format | Article |
| id | doaj-art-4e46795d49f2443ead81545f1a260135 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-4e46795d49f2443ead81545f1a2601352025-02-03T04:04:21ZengTsinghua University PressFood Science and Human Wellness2213-45302020-06-0192184191Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactoseRong Liu0Zukang Fu1Fengjie Zhang2Qingzhong Mao3Chunguang Luan4Xinglin Han5Jie Xue6Deliang Wang7Si Qin8Feike Hao9College of Food Science and Technology, Hunan Agricultural University, Changsha, 410128, China; China National Research Institute of Food and Fermentation Industries, Beijing, 100015, ChinaKuaijishan Shaoxing Rice Wine CO. Ltd., Shaoxing, 312030, ChinaChina National Research Institute of Food and Fermentation Industries, Beijing, 100015, ChinaKuaijishan Shaoxing Rice Wine CO. Ltd., Shaoxing, 312030, ChinaChina National Research Institute of Food and Fermentation Industries, Beijing, 100015, ChinaChina National Research Institute of Food and Fermentation Industries, Beijing, 100015, ChinaChina National Research Institute of Food and Fermentation Industries, Beijing, 100015, ChinaChina National Research Institute of Food and Fermentation Industries, Beijing, 100015, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha, 410128, China; Corresponding author at: College of Food Science and Technology, Hunan Agricultural University, No. 1 Nongda Road, Furong District, Changsha, China.China National Research Institute of Food and Fermentation Industries, Beijing, 100015, China; Corresponding author at: China National Research Institute of Food and Fermentation Industries, No. 24, Jiuxianqiao Middle Road, Chaoyang District, Beijing, 100015, China.The present study is focused on investigation of the health protective effect of yellow rice wine (YRW) in mice and the potential underlying mechanism. Symptoms of aging were induced in mice by using D-galactose (D-gal), and different doses of YRW (4, 8, and 12 mL/kg BW) were orally administrated to D-gal-treated mice for a period of six weeks. The in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and liver. Furthermore, a forced swim test showed that moderate intake of YRW (8 mL/kg BW) significantly decreased the duration of immobility, reduced the blood content of urea nitrogen and lactic acid, and increased hepatic glycogen storage. Besides, results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3. The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action.http://www.sciencedirect.com/science/article/pii/S2213453019301703Yellow rice wineAgingAntioxidantAntifatigueCognitive impairmentApoptosis |
| spellingShingle | Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose Food Science and Human Wellness Yellow rice wine Aging Antioxidant Antifatigue Cognitive impairment Apoptosis |
| title | Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose |
| title_full | Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose |
| title_fullStr | Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose |
| title_full_unstemmed | Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose |
| title_short | Effect of yellow rice wine on anti-aging ability in aged mice induced by d-galactose |
| title_sort | effect of yellow rice wine on anti aging ability in aged mice induced by d galactose |
| topic | Yellow rice wine Aging Antioxidant Antifatigue Cognitive impairment Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019301703 |
| work_keys_str_mv | AT rongliu effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT zukangfu effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT fengjiezhang effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT qingzhongmao effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT chunguangluan effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT xinglinhan effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT jiexue effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT deliangwang effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT siqin effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose AT feikehao effectofyellowricewineonantiagingabilityinagedmiceinducedbydgalactose |