Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know?
Post-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic disorders following beta-hemolytic Streptococcus group A (GAS) infection, hypothesized to be caused by autoimmune mechanisms targeting th...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1477893/full |
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| author | Veronica Maria Tagi Veronica Maria Tagi Martina Tosi Martina Tosi Ilenia Pia Greco Eliana Stucchi Elvira Verduci Elvira Verduci Gianvincenzo Zuccotti Gianvincenzo Zuccotti |
| author_facet | Veronica Maria Tagi Veronica Maria Tagi Martina Tosi Martina Tosi Ilenia Pia Greco Eliana Stucchi Elvira Verduci Elvira Verduci Gianvincenzo Zuccotti Gianvincenzo Zuccotti |
| author_sort | Veronica Maria Tagi |
| collection | DOAJ |
| description | Post-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic disorders following beta-hemolytic Streptococcus group A (GAS) infection, hypothesized to be caused by autoimmune mechanisms targeting the basal ganglia. Scant literature is available regarding the microbiota composition in children with PANDAS, however few studies support the hypothesis that streptococcal infections may alter gut microbiota composition in these patients, leading to chronic inflammation that may impact the brain function and behavior. Notable changes include reduced microbial diversity and shifts in bacterial populations, which affect metabolic functions crucial for neuroinflammation. Elevated serum levels of sNOX2-dp and isoprostanes indicate oxidative stress, while the presence of lipopolysaccharides (LPS) may contribute to neuroinflammation. The aim of this narrative review is to explore the link between PANDAS and gut microbiota composition. The potential connection between gut microbiota and neuropsychiatric symptoms in PANDAS might suggest the importance of dietary interventions, such as promoting the Mediterranean diet and fiber intake, to reduce the inflammatory state of this patients and therefore improve their outcome. |
| format | Article |
| id | doaj-art-4e4553e4246743c88231bd1e18324fcb |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-4e4553e4246743c88231bd1e18324fcb2025-01-06T05:13:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14778931477893Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know?Veronica Maria Tagi0Veronica Maria Tagi1Martina Tosi2Martina Tosi3Ilenia Pia Greco4Eliana Stucchi5Elvira Verduci6Elvira Verduci7Gianvincenzo Zuccotti8Gianvincenzo Zuccotti9Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, ItalyDepartment of Biomedical and Clinical Science, University of Milan, Milan, ItalyDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, ItalyDepartment of Health Sciences, University of Milan, Milan, ItalyDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, ItalyDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, ItalyDepartment of Health Sciences, University of Milan, Milan, ItalyMetabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, ItalyDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, ItalyDepartment of Biomedical and Clinical Science, University of Milan, Milan, ItalyPost-streptococcal autoimmune neuropsychiatric disorders (PANDAS) are a group of pathological condition characterized by sudden-onset obsessive-compulsive and tic disorders following beta-hemolytic Streptococcus group A (GAS) infection, hypothesized to be caused by autoimmune mechanisms targeting the basal ganglia. Scant literature is available regarding the microbiota composition in children with PANDAS, however few studies support the hypothesis that streptococcal infections may alter gut microbiota composition in these patients, leading to chronic inflammation that may impact the brain function and behavior. Notable changes include reduced microbial diversity and shifts in bacterial populations, which affect metabolic functions crucial for neuroinflammation. Elevated serum levels of sNOX2-dp and isoprostanes indicate oxidative stress, while the presence of lipopolysaccharides (LPS) may contribute to neuroinflammation. The aim of this narrative review is to explore the link between PANDAS and gut microbiota composition. The potential connection between gut microbiota and neuropsychiatric symptoms in PANDAS might suggest the importance of dietary interventions, such as promoting the Mediterranean diet and fiber intake, to reduce the inflammatory state of this patients and therefore improve their outcome.https://www.frontiersin.org/articles/10.3389/fnut.2024.1477893/fullPANDASgut microbiotanutritiondietgut-brain axisoxidative stress |
| spellingShingle | Veronica Maria Tagi Veronica Maria Tagi Martina Tosi Martina Tosi Ilenia Pia Greco Eliana Stucchi Elvira Verduci Elvira Verduci Gianvincenzo Zuccotti Gianvincenzo Zuccotti Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? Frontiers in Nutrition PANDAS gut microbiota nutrition diet gut-brain axis oxidative stress |
| title | Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? |
| title_full | Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? |
| title_fullStr | Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? |
| title_full_unstemmed | Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? |
| title_short | Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition: what do we know? |
| title_sort | pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and gut microbiota composition what do we know |
| topic | PANDAS gut microbiota nutrition diet gut-brain axis oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1477893/full |
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