Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment
Abstract With an aging population seeking infertility treatment, diminished ovarian reserve (DOR) is a prevalent indication for assisted reproductive technology (ART). This study aims to investigate the relationship between sleep parameters and DOR among women attending an infertility clinic. Method...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-78123-w |
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| author | Xue-Fen Cai Bi-Ying Wang Jian-Ming Zhao Mei-Xin Nian Qi-Chang Lin Jie-Feng Huang |
| author_facet | Xue-Fen Cai Bi-Ying Wang Jian-Ming Zhao Mei-Xin Nian Qi-Chang Lin Jie-Feng Huang |
| author_sort | Xue-Fen Cai |
| collection | DOAJ |
| description | Abstract With an aging population seeking infertility treatment, diminished ovarian reserve (DOR) is a prevalent indication for assisted reproductive technology (ART). This study aims to investigate the relationship between sleep parameters and DOR among women attending an infertility clinic. Methods We consecutively enrolled women attending an infertility clinic from July 2020 to June 2021. Participants completed the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale(ESS), and STOP-Bang Questionnaire to assess self-reported sleep quality. DOR-related indices including antral follicle count, anti-Müllerian hormone(AMH), follicle-stimulating hormone (FSH) were evaluated. A total of 979 women were enrolled, with 148 classified into the DOR group and 831 in the non-DOR group. The DOR group was notably older compared to the non-DOR group. Analysis showed that the DOR group exhibited significantly shorter sleep onset latency (p = 0.001) and shorter total sleep duration (p = 0.014) compared to the non-DOR group. Logistic regression analysis identified age, PSQI-sleep latency, and PSQI score as independent factors associated with an increased risk of DOR(all p < 0.05). Furthermore, stratified analysis by age group revealed that snoring and PSQI-sleep latency were particularly notable risk factors for DOR among women aged 35 years and older (OR = 2.489, p = 0.040; OR = 2.007, p = 0.008, respectively). Our study highlights that shorter sleep onset latency and shorter total sleep duration may be associated with DOR among women undergoing ART treatments. Particularly noteworthy, snoring and sleep latency were identified as additional risk factors for DOR among women aged 35 years and older. |
| format | Article |
| id | doaj-art-4e4239b947fb49e6841054d8d4a8693d |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-4e4239b947fb49e6841054d8d4a8693d2025-08-20T02:22:26ZengNature PortfolioScientific Reports2045-23222024-11-011411810.1038/s41598-024-78123-wAssociation of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatmentXue-Fen Cai0Bi-Ying Wang1Jian-Ming Zhao2Mei-Xin Nian3Qi-Chang Lin4Jie-Feng Huang5Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical UniversityDepartment of respiratory and critical care medicine, Institute of Respiratory Disease, First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Provincial Sleep-disordered Breathing Clinic CenterDepartment of respiratory and critical care medicine, Institute of Respiratory Disease, First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Provincial Sleep-disordered Breathing Clinic CenterDepartment of respiratory and critical care medicine, Institute of Respiratory Disease, First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Provincial Sleep-disordered Breathing Clinic CenterDepartment of respiratory and critical care medicine, Institute of Respiratory Disease, First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Provincial Sleep-disordered Breathing Clinic CenterDepartment of respiratory and critical care medicine, Institute of Respiratory Disease, First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Provincial Sleep-disordered Breathing Clinic CenterAbstract With an aging population seeking infertility treatment, diminished ovarian reserve (DOR) is a prevalent indication for assisted reproductive technology (ART). This study aims to investigate the relationship between sleep parameters and DOR among women attending an infertility clinic. Methods We consecutively enrolled women attending an infertility clinic from July 2020 to June 2021. Participants completed the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale(ESS), and STOP-Bang Questionnaire to assess self-reported sleep quality. DOR-related indices including antral follicle count, anti-Müllerian hormone(AMH), follicle-stimulating hormone (FSH) were evaluated. A total of 979 women were enrolled, with 148 classified into the DOR group and 831 in the non-DOR group. The DOR group was notably older compared to the non-DOR group. Analysis showed that the DOR group exhibited significantly shorter sleep onset latency (p = 0.001) and shorter total sleep duration (p = 0.014) compared to the non-DOR group. Logistic regression analysis identified age, PSQI-sleep latency, and PSQI score as independent factors associated with an increased risk of DOR(all p < 0.05). Furthermore, stratified analysis by age group revealed that snoring and PSQI-sleep latency were particularly notable risk factors for DOR among women aged 35 years and older (OR = 2.489, p = 0.040; OR = 2.007, p = 0.008, respectively). Our study highlights that shorter sleep onset latency and shorter total sleep duration may be associated with DOR among women undergoing ART treatments. Particularly noteworthy, snoring and sleep latency were identified as additional risk factors for DOR among women aged 35 years and older.https://doi.org/10.1038/s41598-024-78123-wDORSleep onset latencySleep durationSnoring |
| spellingShingle | Xue-Fen Cai Bi-Ying Wang Jian-Ming Zhao Mei-Xin Nian Qi-Chang Lin Jie-Feng Huang Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment Scientific Reports DOR Sleep onset latency Sleep duration Snoring |
| title | Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment |
| title_full | Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment |
| title_fullStr | Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment |
| title_full_unstemmed | Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment |
| title_short | Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment |
| title_sort | association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment |
| topic | DOR Sleep onset latency Sleep duration Snoring |
| url | https://doi.org/10.1038/s41598-024-78123-w |
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