Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device
Summary: Left ventricular assist devices (LVADs) provide an effective artificial support treatment for patients with advanced-stage heart failure. To enhance the LVAD performance and optimize its internal flow field, different blade trailing edge treatment techniques are employed. This study mainly...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422501483X |
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| author | Fuqiang Lai Changsheng Cao Yumei Li Zhihuang Qiu Liangwan Chen |
| author_facet | Fuqiang Lai Changsheng Cao Yumei Li Zhihuang Qiu Liangwan Chen |
| author_sort | Fuqiang Lai |
| collection | DOAJ |
| description | Summary: Left ventricular assist devices (LVADs) provide an effective artificial support treatment for patients with advanced-stage heart failure. To enhance the LVAD performance and optimize its internal flow field, different blade trailing edge treatment techniques are employed. This study mainly investigates the effects of two methods: bladelet and blade trimming. The effectiveness of these two techniques in LVADs has not been thoroughly evaluated in previous research. The flow field distribution and hydraulic performance of different impellers are obtained by computational fluid dynamics (CFD) simulations. The results reveal that bladelets can significantly weaken the hydraulic performance of LVADs. However, the appropriate bladelet parameters can reduce the hemolysis value and improve hemocompatibility. Similarly, suitable blade trimming parameters can optimize the hemocompatibility of LVADs. Nevertheless, excessive blade trimming can increase hemolysis. Lastly, blade trimming has minimal impact on the hydraulic performance of LVADs. |
| format | Article |
| id | doaj-art-4e32a1e095bc411f9d5fd26b7a4eeeb7 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-4e32a1e095bc411f9d5fd26b7a4eeeb72025-08-22T04:57:07ZengElsevieriScience2589-00422025-09-0128911322210.1016/j.isci.2025.113222Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist deviceFuqiang Lai0Changsheng Cao1Yumei Li2Zhihuang Qiu3Liangwan Chen4Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, China; School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, Fujian, ChinaSchool of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, Fujian, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, China; Corresponding authorDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, China; Corresponding authorSummary: Left ventricular assist devices (LVADs) provide an effective artificial support treatment for patients with advanced-stage heart failure. To enhance the LVAD performance and optimize its internal flow field, different blade trailing edge treatment techniques are employed. This study mainly investigates the effects of two methods: bladelet and blade trimming. The effectiveness of these two techniques in LVADs has not been thoroughly evaluated in previous research. The flow field distribution and hydraulic performance of different impellers are obtained by computational fluid dynamics (CFD) simulations. The results reveal that bladelets can significantly weaken the hydraulic performance of LVADs. However, the appropriate bladelet parameters can reduce the hemolysis value and improve hemocompatibility. Similarly, suitable blade trimming parameters can optimize the hemocompatibility of LVADs. Nevertheless, excessive blade trimming can increase hemolysis. Lastly, blade trimming has minimal impact on the hydraulic performance of LVADs.http://www.sciencedirect.com/science/article/pii/S258900422501483XSurgeryCardiovascular medicine |
| spellingShingle | Fuqiang Lai Changsheng Cao Yumei Li Zhihuang Qiu Liangwan Chen Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device iScience Surgery Cardiovascular medicine |
| title | Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device |
| title_full | Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device |
| title_fullStr | Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device |
| title_full_unstemmed | Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device |
| title_short | Effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device |
| title_sort | effect of blade trailing edge treatment on the hemolysis and hydraulic performance of left ventricular assist device |
| topic | Surgery Cardiovascular medicine |
| url | http://www.sciencedirect.com/science/article/pii/S258900422501483X |
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