Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography
Abstract Background The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Op...
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BMC
2025-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03837-4 |
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| author | Okan Akmaz Murat Gokhan Tokac Murat Garli Tuncay Kusbeci |
| author_facet | Okan Akmaz Murat Gokhan Tokac Murat Garli Tuncay Kusbeci |
| author_sort | Okan Akmaz |
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| description | Abstract Background The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Open Angle Glaucoma (POAG) and Pseudoexfoliation Glaucoma (PXG) eyes. Methods 60 POAG and 60 PXG patients and 30 control group patients were included in the study. Patients diagnosed with glaucoma were divided into two groups as mild (Mean deviation (MD) > -6.00) and moderate-severe (MD < -6.00). The average, superior and inferior quadrant thinning rates (expressed in micrometers per year) of GCIPL and RNFL in the OCT GPA program were compared between groups. Results Average GCIPL thinning rates were -0.23 ± 0.21 μm/year in the control group, -0.64 ± 0.54 μm/year in POAG patients, and -1.06 ± 1.16 μm/year in PXG patients (ANOVA, p < 0.001). Average RNFL thinning rates were -0.33 ± 0.44 μm/year in the control group, -0.86 ± 0.73 μm/year in POAG patients, and -1.33 ± 1.4 μm/year in PXG patients (ANOVA, p < 0.001). Conclusions The rates of GCIPL and RNFL thinning were highest in patients with PXG. We found that the glaucoma stage did not affect the rate of RNFL and GCIPL thinning. |
| format | Article |
| id | doaj-art-4e31e9ee998645479c9c3571cb41f007 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-4e31e9ee998645479c9c3571cb41f0072025-01-05T12:11:50ZengBMCBMC Ophthalmology1471-24152025-01-012511910.1186/s12886-024-03837-4Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomographyOkan Akmaz0Murat Gokhan Tokac1Murat Garli2Tuncay Kusbeci3Department of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research HospitalDepartment of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research HospitalDepartment of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research HospitalDepartment of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research HospitalAbstract Background The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Open Angle Glaucoma (POAG) and Pseudoexfoliation Glaucoma (PXG) eyes. Methods 60 POAG and 60 PXG patients and 30 control group patients were included in the study. Patients diagnosed with glaucoma were divided into two groups as mild (Mean deviation (MD) > -6.00) and moderate-severe (MD < -6.00). The average, superior and inferior quadrant thinning rates (expressed in micrometers per year) of GCIPL and RNFL in the OCT GPA program were compared between groups. Results Average GCIPL thinning rates were -0.23 ± 0.21 μm/year in the control group, -0.64 ± 0.54 μm/year in POAG patients, and -1.06 ± 1.16 μm/year in PXG patients (ANOVA, p < 0.001). Average RNFL thinning rates were -0.33 ± 0.44 μm/year in the control group, -0.86 ± 0.73 μm/year in POAG patients, and -1.33 ± 1.4 μm/year in PXG patients (ANOVA, p < 0.001). Conclusions The rates of GCIPL and RNFL thinning were highest in patients with PXG. We found that the glaucoma stage did not affect the rate of RNFL and GCIPL thinning.https://doi.org/10.1186/s12886-024-03837-4Guided progression analysisOptical coherence tomographyPrimary open angle glaucomaPseudoexfoliation glaucoma |
| spellingShingle | Okan Akmaz Murat Gokhan Tokac Murat Garli Tuncay Kusbeci Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography BMC Ophthalmology Guided progression analysis Optical coherence tomography Primary open angle glaucoma Pseudoexfoliation glaucoma |
| title | Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography |
| title_full | Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography |
| title_fullStr | Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography |
| title_full_unstemmed | Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography |
| title_short | Comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography |
| title_sort | comparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography |
| topic | Guided progression analysis Optical coherence tomography Primary open angle glaucoma Pseudoexfoliation glaucoma |
| url | https://doi.org/10.1186/s12886-024-03837-4 |
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