Evaluation of serum folic acid level in patients with type 2 diabetes mellitus
Background and objectives: Type-2 diabetes mellitus is a metabolic disorder. Diabetic patients with low folic acid, high homocysteine levels, have a higher chance of developing coronary heart disease based on previous studies. Therefore, this study aimed to investigate the serum levels of folic aci...
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Kurdistan Higher Council Of Medical Specialties
2024-06-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/428 |
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| author | Viyan Mahmood Ali Sherwan Ferman Salih Dhia Mustafa Sulaiman |
| author_facet | Viyan Mahmood Ali Sherwan Ferman Salih Dhia Mustafa Sulaiman |
| author_sort | Viyan Mahmood Ali |
| collection | DOAJ |
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Background and objectives: Type-2 diabetes mellitus is a metabolic disorder. Diabetic patients with low folic acid, high homocysteine levels, have a higher chance of developing coronary heart disease based on previous studies. Therefore, this study aimed to investigate the serum levels of folic acid and homocysteine in type-2 diabetes mellitus patients and their association with insulin resistance.
Methods: This cross-sectional study has been conducted on 138 participants from February 2nd 2022 to August 3rd 2022, at Azadi teaching hospital/clinical biochemistry department- Duhok, Kurdistan region, Iraq. The participants were composed of two groups, 70 patients with type-2 diabetes mellitus, and 68 apparently healthy control. Both groups have been investigated for serum folic acid level, serum glucose, serum insulin, serum homocysteine, glycosylated hemoglobin, and Homeostatic Model Assessment for Insulin Resistance.
Results: The mean age for type 2 diabetic patients was (51.24 years) with males predominant (64.29%). Type 2 diabetic patients showed a low level of mean serum folic acid concentrations (2.73 ng/ml) in comparison with healthy subjects (5.91 ng/ml) (p<0.001), and the mean serum homocysteine concentration was (13.493 ?mol/L) among type 2 diabetic patients compared to healthy subjects (10.041 ?mol/L) (p<0.001). Significant correlation was found between serum folic acid and serum homocysteine levels, and glycosylated hemoglobin (p<0.05 and p<0.001, respectively).
Conclusion: Patients with type-2 diabetes mellitus were associated with low mean serum folic acid levels and high mean serum homocysteine levels.
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| format | Article |
| id | doaj-art-4e2d3fb2a2074e6f99d31a0e3ea11a5a |
| institution | OA Journals |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-4e2d3fb2a2074e6f99d31a0e3ea11a5a2025-08-20T02:17:33ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802024-06-019210.56056/amj.2024.268429Evaluation of serum folic acid level in patients with type 2 diabetes mellitusViyan Mahmood Ali0Sherwan Ferman Salih1Dhia Mustafa Sulaiman2M.B.Ch.B, Azadi general teaching hospital, DuhokM.B.Ch.B, Assistant professor of Clinical biochemistry, department of medical chemistry, college of medicine, university of Duhok, M.B.Ch.B, Assistant professor of Clinical biochemistry, Duhok Polytechnique University, Duhok, Background and objectives: Type-2 diabetes mellitus is a metabolic disorder. Diabetic patients with low folic acid, high homocysteine levels, have a higher chance of developing coronary heart disease based on previous studies. Therefore, this study aimed to investigate the serum levels of folic acid and homocysteine in type-2 diabetes mellitus patients and their association with insulin resistance. Methods: This cross-sectional study has been conducted on 138 participants from February 2nd 2022 to August 3rd 2022, at Azadi teaching hospital/clinical biochemistry department- Duhok, Kurdistan region, Iraq. The participants were composed of two groups, 70 patients with type-2 diabetes mellitus, and 68 apparently healthy control. Both groups have been investigated for serum folic acid level, serum glucose, serum insulin, serum homocysteine, glycosylated hemoglobin, and Homeostatic Model Assessment for Insulin Resistance. Results: The mean age for type 2 diabetic patients was (51.24 years) with males predominant (64.29%). Type 2 diabetic patients showed a low level of mean serum folic acid concentrations (2.73 ng/ml) in comparison with healthy subjects (5.91 ng/ml) (p<0.001), and the mean serum homocysteine concentration was (13.493 ?mol/L) among type 2 diabetic patients compared to healthy subjects (10.041 ?mol/L) (p<0.001). Significant correlation was found between serum folic acid and serum homocysteine levels, and glycosylated hemoglobin (p<0.05 and p<0.001, respectively). Conclusion: Patients with type-2 diabetes mellitus were associated with low mean serum folic acid levels and high mean serum homocysteine levels. https://amj.khcms.edu.krd/index.php/main/article/view/428Folic acidHomocysteineInsulin resistanceType 2 diabetes mellitus |
| spellingShingle | Viyan Mahmood Ali Sherwan Ferman Salih Dhia Mustafa Sulaiman Evaluation of serum folic acid level in patients with type 2 diabetes mellitus Advanced Medical Journal Folic acid Homocysteine Insulin resistance Type 2 diabetes mellitus |
| title | Evaluation of serum folic acid level in patients with type 2 diabetes mellitus |
| title_full | Evaluation of serum folic acid level in patients with type 2 diabetes mellitus |
| title_fullStr | Evaluation of serum folic acid level in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Evaluation of serum folic acid level in patients with type 2 diabetes mellitus |
| title_short | Evaluation of serum folic acid level in patients with type 2 diabetes mellitus |
| title_sort | evaluation of serum folic acid level in patients with type 2 diabetes mellitus |
| topic | Folic acid Homocysteine Insulin resistance Type 2 diabetes mellitus |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/428 |
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