The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review
Objective. To provide a narrative review of the most recent data concerning the involvement of the microbiome in the pathogenesis of connective tissue diseases (CTDs) and vasculitides. Methods. The PubMed database was searched for articles using combinations of words or terms that included systemic...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6836498 |
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| author | Rossella Talotta Fabiola Atzeni Maria Chiara Ditto Maria Chiara Gerardi Piercarlo Sarzi-Puttini |
| author_facet | Rossella Talotta Fabiola Atzeni Maria Chiara Ditto Maria Chiara Gerardi Piercarlo Sarzi-Puttini |
| author_sort | Rossella Talotta |
| collection | DOAJ |
| description | Objective. To provide a narrative review of the most recent data concerning the involvement of the microbiome in the pathogenesis of connective tissue diseases (CTDs) and vasculitides. Methods. The PubMed database was searched for articles using combinations of words or terms that included systemic lupus erythematosus, systemic sclerosis, autoimmune myositis, Sjögren’s syndrome, undifferentiated and mixed CTD, vasculitis, microbiota, microbiome, and dysbiosis. Papers from the reference lists of the articles and book chapters were reviewed, and relevant publications were identified. Abstracts and articles written in languages other than English were excluded. Results. We found some evidence that dysbiosis participates in the pathogenesis of systemic lupus erythematosus, systemic sclerosis, Sjögren’s syndrome, and Behçet’s disease, but there are still few data concerning the role of dysbiosis in other CTDs or vasculitides. Conclusions. Numerous studies suggest that alterations in human microbiota may be involved in the pathogenesis of inflammatory arthritides as a result of the aberrant activation of the innate and adaptive immune responses. Only a few studies have explored the involvement of dysbiosis in other CTDs or vasculitides, and further research is needed. |
| format | Article |
| id | doaj-art-4e2cfb64a4a44f7687055dbbeb2cc323 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-4e2cfb64a4a44f7687055dbbeb2cc3232025-02-03T01:02:56ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/68364986836498The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative ReviewRossella Talotta0Fabiola Atzeni1Maria Chiara Ditto2Maria Chiara Gerardi3Piercarlo Sarzi-Puttini4Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, ItalyIRCCS Galeazzi Orthopedic Institute, Milan, ItalyDepartment of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, ItalyDepartment of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, ItalyDepartment of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, ItalyObjective. To provide a narrative review of the most recent data concerning the involvement of the microbiome in the pathogenesis of connective tissue diseases (CTDs) and vasculitides. Methods. The PubMed database was searched for articles using combinations of words or terms that included systemic lupus erythematosus, systemic sclerosis, autoimmune myositis, Sjögren’s syndrome, undifferentiated and mixed CTD, vasculitis, microbiota, microbiome, and dysbiosis. Papers from the reference lists of the articles and book chapters were reviewed, and relevant publications were identified. Abstracts and articles written in languages other than English were excluded. Results. We found some evidence that dysbiosis participates in the pathogenesis of systemic lupus erythematosus, systemic sclerosis, Sjögren’s syndrome, and Behçet’s disease, but there are still few data concerning the role of dysbiosis in other CTDs or vasculitides. Conclusions. Numerous studies suggest that alterations in human microbiota may be involved in the pathogenesis of inflammatory arthritides as a result of the aberrant activation of the innate and adaptive immune responses. Only a few studies have explored the involvement of dysbiosis in other CTDs or vasculitides, and further research is needed.http://dx.doi.org/10.1155/2017/6836498 |
| spellingShingle | Rossella Talotta Fabiola Atzeni Maria Chiara Ditto Maria Chiara Gerardi Piercarlo Sarzi-Puttini The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review Journal of Immunology Research |
| title | The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review |
| title_full | The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review |
| title_fullStr | The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review |
| title_full_unstemmed | The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review |
| title_short | The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review |
| title_sort | microbiome in connective tissue diseases and vasculitides an updated narrative review |
| url | http://dx.doi.org/10.1155/2017/6836498 |
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