A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia
Objective and Importance. Invasive mucormycosis may complicate the course of patients with hematologic malignancies and has a very high mortality rate. Early diagnosis and aggressive approach combined with surgical and medical treatment have paramount importance for cure. Clinical Presentation. We r...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/285360 |
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| author | Mehmet Sezgin Pepeler Kadir Acar Özlem Güzel Tunçcan Ömer Uluoğlu Ayşe Kalkancı Hakan Atalar Koray Kılıç Gülsan Türköz Sucak |
| author_facet | Mehmet Sezgin Pepeler Kadir Acar Özlem Güzel Tunçcan Ömer Uluoğlu Ayşe Kalkancı Hakan Atalar Koray Kılıç Gülsan Türköz Sucak |
| author_sort | Mehmet Sezgin Pepeler |
| collection | DOAJ |
| description | Objective and Importance. Invasive mucormycosis may complicate the course of patients with hematologic malignancies and has a very high mortality rate. Early diagnosis and aggressive approach combined with surgical and medical treatment have paramount importance for cure. Clinical Presentation. We report here a case of a patient with acute lymphoblastic leukemia presenting with a subcutaneous mass lesion which was sampled by an ultrasound guided needle biopsy. The pathology showed microorganisms with aseptate hyphae with wide, irregular walls and more or less branching with highly vertical angles which suggested a mold infection. The specimen was also cultured where Rhizopus spp. grew. Conclusion. Posaconazole 200 mg QID was commenced. She recovered from neutropenia and pain on day 20 of treatment. After 4 courses of hyper-CVAD chemotherapy, the remaining soft tissue mass was removed surgically and she underwent allogeneic HSCT from a full matched sibling donor under secondary prophylaxis. |
| format | Article |
| id | doaj-art-4e2b92a0e8d241ddb41552a432f0c0b8 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4e2b92a0e8d241ddb41552a432f0c0b82025-08-20T02:38:46ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/285360285360A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic LeukemiaMehmet Sezgin Pepeler0Kadir Acar1Özlem Güzel Tunçcan2Ömer Uluoğlu3Ayşe Kalkancı4Hakan Atalar5Koray Kılıç6Gülsan Türköz Sucak7Department of Hematology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Hematology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Infectious Disease, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Pathology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Microbiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Orthopedics, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Radiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Hematology, Gazi University Faculty of Medicine, Ankara, TurkeyObjective and Importance. Invasive mucormycosis may complicate the course of patients with hematologic malignancies and has a very high mortality rate. Early diagnosis and aggressive approach combined with surgical and medical treatment have paramount importance for cure. Clinical Presentation. We report here a case of a patient with acute lymphoblastic leukemia presenting with a subcutaneous mass lesion which was sampled by an ultrasound guided needle biopsy. The pathology showed microorganisms with aseptate hyphae with wide, irregular walls and more or less branching with highly vertical angles which suggested a mold infection. The specimen was also cultured where Rhizopus spp. grew. Conclusion. Posaconazole 200 mg QID was commenced. She recovered from neutropenia and pain on day 20 of treatment. After 4 courses of hyper-CVAD chemotherapy, the remaining soft tissue mass was removed surgically and she underwent allogeneic HSCT from a full matched sibling donor under secondary prophylaxis.http://dx.doi.org/10.1155/2015/285360 |
| spellingShingle | Mehmet Sezgin Pepeler Kadir Acar Özlem Güzel Tunçcan Ömer Uluoğlu Ayşe Kalkancı Hakan Atalar Koray Kılıç Gülsan Türköz Sucak A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia Case Reports in Hematology |
| title | A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia |
| title_full | A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia |
| title_fullStr | A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia |
| title_full_unstemmed | A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia |
| title_short | A Proven Case of Cutaneous Rhizopus Infection Presenting with Severe Limb Pain Very Soon after Induction Treatment in a Patient with Acute Lymphoblastic Leukemia |
| title_sort | proven case of cutaneous rhizopus infection presenting with severe limb pain very soon after induction treatment in a patient with acute lymphoblastic leukemia |
| url | http://dx.doi.org/10.1155/2015/285360 |
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