Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes
Aim. To study such circulating angiogenesis factors as vascular endothelial growth factor (VEGF-A), hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), as well as the cytokine profile (IL-1β, TNF-α, IL-6, IL-8, IL-23) and their soluble receptors (SRp55 TNF-α, SR IL-6) in the blood se...
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«FIRMA «SILICEA» LLC
2021-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4328 |
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| author | T. A. Medvedeva N. N. Kushnarenko M. Yu. Mishko T. M. Karavaeva E. V. Volgina |
| author_facet | T. A. Medvedeva N. N. Kushnarenko M. Yu. Mishko T. M. Karavaeva E. V. Volgina |
| author_sort | T. A. Medvedeva |
| collection | DOAJ |
| description | Aim. To study such circulating angiogenesis factors as vascular endothelial growth factor (VEGF-A), hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), as well as the cytokine profile (IL-1β, TNF-α, IL-6, IL-8, IL-23) and their soluble receptors (SRp55 TNF-α, SR IL-6) in the blood serum of gout patients having various obesity phenotypes.Material and methods. The study included 112 male patients with intercritical gout. The patients were divided into 2 study groups: the 1st group consisted of 39 patients with a metabolically healthy obesity (MHO) phenotype and body mass index (BMI) ≥25 kg/m2; the 2nd group included 73 people having metabolically unhealthy obesity (MUO) with impaired immune status, hypertension (HTN) and class 1 abdominal obesity. The control group consisted of 25 metabolically healthy subjects with normal body weight. Serum concentration of uric acid, CRP, insulin, leptin, insulin resistance index (HOMA-IR), cytokine status, plasma levels of VEGF-A, HGF, IGF-1 were studied. To assess the left ventricular (LV) diastolic function, tissue Doppler imaging of the mitral annulus was used.Results. In the group of patients with MUO, an increase of pro-inflammatory cytokines (IL-1β, IL-6, IL-23, TNF-α, SRp55 TNF-α) was revealed, while the level of TNF-α and IL-1β exceeds the control values in 4,7 and 6,8 times, respectively (p <0,05), and in the group of patients with MHO, 1,4 and 1,6 times, respectively (p<0,05). Correlations between VEGF-A and TNF-α (r=0,59, p<0,0001), IL-6 (r=0,68, p<0,001), CRP (r=0,59, p<0,0001), serum uric acid level (r=0,47, p<0,0001), decrease in high-density lipoprotein cholesterol (HDL-C) (r=-0,28, p<0,05) and diastolic blood pressure (r=0,51, p<0,0001) were determined. The concentration of HGF and VEGF-A correlated with BMI (p<0,001). Associations of IGF-1 and HGF with hyperuricemia, carbohydrate metabolism and diastolic remodeling were established.Conclusion. The relationship between circulating levels of VEGF-A, HGF and IGF-1 with indicators of cytokine status, carbohydrate metabolism and Doppler imaging criteria for LV diastolic dysfunction allows to consider them as additional predictors of unfavorable cardiovascular risk. |
| format | Article |
| id | doaj-art-4e2990575ae44172a8c6a23cd8db7e2e |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2021-04-01 |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-4e2990575ae44172a8c6a23cd8db7e2e2025-08-20T03:43:39Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-04-0126310.15829/1560-4071-2021-43283166Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypesT. A. Medvedeva0N. N. Kushnarenko1M. Yu. Mishko2T. M. Karavaeva3E. V. Volgina4Chita State Medical AcademyChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyAim. To study such circulating angiogenesis factors as vascular endothelial growth factor (VEGF-A), hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), as well as the cytokine profile (IL-1β, TNF-α, IL-6, IL-8, IL-23) and their soluble receptors (SRp55 TNF-α, SR IL-6) in the blood serum of gout patients having various obesity phenotypes.Material and methods. The study included 112 male patients with intercritical gout. The patients were divided into 2 study groups: the 1st group consisted of 39 patients with a metabolically healthy obesity (MHO) phenotype and body mass index (BMI) ≥25 kg/m2; the 2nd group included 73 people having metabolically unhealthy obesity (MUO) with impaired immune status, hypertension (HTN) and class 1 abdominal obesity. The control group consisted of 25 metabolically healthy subjects with normal body weight. Serum concentration of uric acid, CRP, insulin, leptin, insulin resistance index (HOMA-IR), cytokine status, plasma levels of VEGF-A, HGF, IGF-1 were studied. To assess the left ventricular (LV) diastolic function, tissue Doppler imaging of the mitral annulus was used.Results. In the group of patients with MUO, an increase of pro-inflammatory cytokines (IL-1β, IL-6, IL-23, TNF-α, SRp55 TNF-α) was revealed, while the level of TNF-α and IL-1β exceeds the control values in 4,7 and 6,8 times, respectively (p <0,05), and in the group of patients with MHO, 1,4 and 1,6 times, respectively (p<0,05). Correlations between VEGF-A and TNF-α (r=0,59, p<0,0001), IL-6 (r=0,68, p<0,001), CRP (r=0,59, p<0,0001), serum uric acid level (r=0,47, p<0,0001), decrease in high-density lipoprotein cholesterol (HDL-C) (r=-0,28, p<0,05) and diastolic blood pressure (r=0,51, p<0,0001) were determined. The concentration of HGF and VEGF-A correlated with BMI (p<0,001). Associations of IGF-1 and HGF with hyperuricemia, carbohydrate metabolism and diastolic remodeling were established.Conclusion. The relationship between circulating levels of VEGF-A, HGF and IGF-1 with indicators of cytokine status, carbohydrate metabolism and Doppler imaging criteria for LV diastolic dysfunction allows to consider them as additional predictors of unfavorable cardiovascular risk.https://russjcardiol.elpub.ru/jour/article/view/4328goutobesitygrowth factorscytokinesdiastolic dysfunction |
| spellingShingle | T. A. Medvedeva N. N. Kushnarenko M. Yu. Mishko T. M. Karavaeva E. V. Volgina Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes Российский кардиологический журнал gout obesity growth factors cytokines diastolic dysfunction |
| title | Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes |
| title_full | Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes |
| title_fullStr | Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes |
| title_full_unstemmed | Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes |
| title_short | Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes |
| title_sort | clinical and pathogenetic significance of angiogenesis factors vegf a hgf igf 1 in the development of cardiometabolic disorders in gout patients having different obesity phenotypes |
| topic | gout obesity growth factors cytokines diastolic dysfunction |
| url | https://russjcardiol.elpub.ru/jour/article/view/4328 |
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