Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections

Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections

Abstract Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or brain and cerebrospinal fluid (meningitis). Meningitis remains an important global health...

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Bibliographic Details
Main Authors: Niels Vander Elst, Kristine Farmen, Lisa Knörr, Lotte Merlijn, Federico Iovino
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Streptococcus pneumoniae
Invasive Pneumococcal Disease
Meningitis
Antibiotic-resistance
Endolysins
Penicillin
Online Access:https://doi.org/10.1186/s10020-025-01226-1
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