Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus
Abstract In recent years, microbial infections have become the most common and the leading cause of death worldwide. From them, the Gram-positive bacterial strain Staphylococcus aureus is a highly effective pathogen that can infect almost every human body tissue, from minor skin diseases to life-thr...
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| Format: | Article |
| Language: | English |
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Springer
2025-03-01
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| Series: | Discover Chemistry |
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| Online Access: | https://doi.org/10.1007/s44371-025-00134-x |
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| author | Pooja Tandel Zebabanu Khalifa Rachana Upadhyay Amit B. Patel |
| author_facet | Pooja Tandel Zebabanu Khalifa Rachana Upadhyay Amit B. Patel |
| author_sort | Pooja Tandel |
| collection | DOAJ |
| description | Abstract In recent years, microbial infections have become the most common and the leading cause of death worldwide. From them, the Gram-positive bacterial strain Staphylococcus aureus is a highly effective pathogen that can infect almost every human body tissue, from minor skin diseases to life-threatening infections. Antibiotics are generally used to treat microbial infections, but due to their excessive and careless usage, microorganisms have gradually developed resistance to them. Therefore, it is necessary to develop novel drugs that minimize drug resistance. Many microbial drugs are available in the market but they are not as effective as before. Currently, coumarin derivatives are highly regarded in medicinal chemistry and favored by new researchers due to their diverse pharmaceutical properties, including antibacterial, anticancer, antitubercular, antioxidant, etc. It also possesses antibiotic qualities as well. Coumarines are commercially available and have long been utilized in clinical treatment. These therapeutic properties of coumarin can help to develop novel antimicrobial agents to treat drug resistance. Hence, this review article provides significant attention to the recent developments and structure–activity relationships (SAR) of C-3 substituted coumarin derivatives to combat infection caused by S. aureus. Graphical abstract |
| format | Article |
| id | doaj-art-4e1f7fc3572b4bb4ae49f3d549b89fba |
| institution | OA Journals |
| issn | 3005-1193 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Chemistry |
| spelling | doaj-art-4e1f7fc3572b4bb4ae49f3d549b89fba2025-08-20T02:10:17ZengSpringerDiscover Chemistry3005-11932025-03-012112710.1007/s44371-025-00134-xInvestigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureusPooja Tandel0Zebabanu Khalifa1Rachana Upadhyay2Amit B. Patel3Department of Chemistry, Government College, Daman (Affiliated to Veer Narmad South Gujarat University, Surat)Department of Chemistry, Government College, Daman (Affiliated to Veer Narmad South Gujarat University, Surat)Department of Chemistry, Government College, Daman (Affiliated to Veer Narmad South Gujarat University, Surat)Department of Chemistry, Government College, Daman (Affiliated to Veer Narmad South Gujarat University, Surat)Abstract In recent years, microbial infections have become the most common and the leading cause of death worldwide. From them, the Gram-positive bacterial strain Staphylococcus aureus is a highly effective pathogen that can infect almost every human body tissue, from minor skin diseases to life-threatening infections. Antibiotics are generally used to treat microbial infections, but due to their excessive and careless usage, microorganisms have gradually developed resistance to them. Therefore, it is necessary to develop novel drugs that minimize drug resistance. Many microbial drugs are available in the market but they are not as effective as before. Currently, coumarin derivatives are highly regarded in medicinal chemistry and favored by new researchers due to their diverse pharmaceutical properties, including antibacterial, anticancer, antitubercular, antioxidant, etc. It also possesses antibiotic qualities as well. Coumarines are commercially available and have long been utilized in clinical treatment. These therapeutic properties of coumarin can help to develop novel antimicrobial agents to treat drug resistance. Hence, this review article provides significant attention to the recent developments and structure–activity relationships (SAR) of C-3 substituted coumarin derivatives to combat infection caused by S. aureus. Graphical abstracthttps://doi.org/10.1007/s44371-025-00134-xC-3 substituted coumarinDicumarolsGram-positive bacterial strainS. aureusIn vitro studyStructure–activity relationships (SAR) |
| spellingShingle | Pooja Tandel Zebabanu Khalifa Rachana Upadhyay Amit B. Patel Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus Discover Chemistry C-3 substituted coumarin Dicumarols Gram-positive bacterial strain S. aureus In vitro study Structure–activity relationships (SAR) |
| title | Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus |
| title_full | Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus |
| title_fullStr | Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus |
| title_full_unstemmed | Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus |
| title_short | Investigation of recent advancement in the pharmacological potential of C-3 substituted coumarin derivatives against S. aureus |
| title_sort | investigation of recent advancement in the pharmacological potential of c 3 substituted coumarin derivatives against s aureus |
| topic | C-3 substituted coumarin Dicumarols Gram-positive bacterial strain S. aureus In vitro study Structure–activity relationships (SAR) |
| url | https://doi.org/10.1007/s44371-025-00134-x |
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