Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications

Salt stress severely limits global crop productivity by disrupting ionic balance, physiological processes, and cellular ultrastructure, particularly in salt-sensitive forages like alfalfa (Medicago sativa L). Addressing this issue requires environmentally feasible and innovative strategies. This stu...

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Main Authors: Hafiz Abdul Kareem, Yongdong Li, Sana Saleem, Adnan Mustafa, Muhammad Azeem, Quanzhen Wang, Song Li, Yi Chen, Xihui Shen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Ecotoxicology and Environmental Safety
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Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325004944
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author Hafiz Abdul Kareem
Yongdong Li
Sana Saleem
Adnan Mustafa
Muhammad Azeem
Quanzhen Wang
Song Li
Yi Chen
Xihui Shen
author_facet Hafiz Abdul Kareem
Yongdong Li
Sana Saleem
Adnan Mustafa
Muhammad Azeem
Quanzhen Wang
Song Li
Yi Chen
Xihui Shen
author_sort Hafiz Abdul Kareem
collection DOAJ
description Salt stress severely limits global crop productivity by disrupting ionic balance, physiological processes, and cellular ultrastructure, particularly in salt-sensitive forages like alfalfa (Medicago sativa L). Addressing this issue requires environmentally feasible and innovative strategies. This study investigated the comparative potential of Nano-FeO and FeSO4 (30 mg kg−1) soil supplements with rhizobium on alfalfa salt tolerance employing morphological, physicochemical, and cellular approaches. The results demonstrated that FITC-nFeO and rhizobium significantly reduced Na+ uptake, enhanced K+ accumulation, and improved the Na+/K+ ratio in alfalfa roots and shoots relative to FeSO4. Scanning electron microscopy illustrated that FITC-nFeO ameliorated root ultracellular structure and leaf stomatal functionality, facilitating improved gaseous exchange characteristics and photosynthetic performance. Confocal laser scanning microscopy confirmed FITC-tagged nFeO adhesion to roots, supported by transmission electron microscopy findings of preserved chloroplast ultrastructure under FITC-nFeO and rhizobium application. FITC-nFeO also mitigated oxidative damage of ROS, as evidenced by reduced hydrogen peroxide, electrolyte leakage, and thiobarbituric acid reactive substances (TBARS) content, through enhanced antioxidant enzyme activities. Overall, in comparison to FeSO4, FITC-nFeO with rhizobium retrieved the salt-induced damages in alfalfa by promoting morpho-physiological and ultracellular integrity. This study highlights the role of nanotechnology in enhancing the resilience of forages on salt-contaminated soils, paving the way for eco-friendly remediation strategies.
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spelling doaj-art-4e1a4c9a8a40437bb8d0fcd2ac5726a32025-08-20T02:16:29ZengElsevierEcotoxicology and Environmental Safety0147-65132025-04-0129511815810.1016/j.ecoenv.2025.118158Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modificationsHafiz Abdul Kareem0Yongdong Li1Sana Saleem2Adnan Mustafa3Muhammad Azeem4Quanzhen Wang5Song Li6Yi Chen7Xihui Shen8State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, PR ChinaNingbo Municipal Center for Disease Control and Prevention, Ningbo Key Laboratory of Virus Research, Ningbo 315010, PR ChinaDepartment of Vegetable Science, College of Horticulture, Northwest A&F University, Yangling 712100, PR ChinaGuangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR ChinaKey Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China; Institute of Soil and Environmental Sciences, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Punjab 46300, PakistanCollege of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi 712100, PR ChinaState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, PR ChinaNingbo Municipal Center for Disease Control and Prevention, Ningbo Key Laboratory of Virus Research, Ningbo 315010, PR ChinaState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, PR China; Corresponding author.Salt stress severely limits global crop productivity by disrupting ionic balance, physiological processes, and cellular ultrastructure, particularly in salt-sensitive forages like alfalfa (Medicago sativa L). Addressing this issue requires environmentally feasible and innovative strategies. This study investigated the comparative potential of Nano-FeO and FeSO4 (30 mg kg−1) soil supplements with rhizobium on alfalfa salt tolerance employing morphological, physicochemical, and cellular approaches. The results demonstrated that FITC-nFeO and rhizobium significantly reduced Na+ uptake, enhanced K+ accumulation, and improved the Na+/K+ ratio in alfalfa roots and shoots relative to FeSO4. Scanning electron microscopy illustrated that FITC-nFeO ameliorated root ultracellular structure and leaf stomatal functionality, facilitating improved gaseous exchange characteristics and photosynthetic performance. Confocal laser scanning microscopy confirmed FITC-tagged nFeO adhesion to roots, supported by transmission electron microscopy findings of preserved chloroplast ultrastructure under FITC-nFeO and rhizobium application. FITC-nFeO also mitigated oxidative damage of ROS, as evidenced by reduced hydrogen peroxide, electrolyte leakage, and thiobarbituric acid reactive substances (TBARS) content, through enhanced antioxidant enzyme activities. Overall, in comparison to FeSO4, FITC-nFeO with rhizobium retrieved the salt-induced damages in alfalfa by promoting morpho-physiological and ultracellular integrity. This study highlights the role of nanotechnology in enhancing the resilience of forages on salt-contaminated soils, paving the way for eco-friendly remediation strategies.http://www.sciencedirect.com/science/article/pii/S0147651325004944Salt stress mitigationHistochemical staining, Na⁺/K⁺ ratio improvementNanoparticles, Ultrastructural stabilityIonic balance regulation
spellingShingle Hafiz Abdul Kareem
Yongdong Li
Sana Saleem
Adnan Mustafa
Muhammad Azeem
Quanzhen Wang
Song Li
Yi Chen
Xihui Shen
Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
Ecotoxicology and Environmental Safety
Salt stress mitigation
Histochemical staining, Na⁺/K⁺ ratio improvement
Nanoparticles, Ultrastructural stability
Ionic balance regulation
title Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
title_full Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
title_fullStr Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
title_full_unstemmed Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
title_short Eco-safe potential of FITC-tagged nFeO in enhancing alfalfa-rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
title_sort eco safe potential of fitc tagged nfeo in enhancing alfalfa rhizobia symbiosis and salt stress tolerance via physicochemical and ultrastructural modifications
topic Salt stress mitigation
Histochemical staining, Na⁺/K⁺ ratio improvement
Nanoparticles, Ultrastructural stability
Ionic balance regulation
url http://www.sciencedirect.com/science/article/pii/S0147651325004944
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