Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties
In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all f...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-06-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2017-0011 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569385950117888 |
|---|---|
| author | Sa Anongtip Sawatdee Somchai Phadoongsombut Narubodee Buatong Wilaiporn Nakpeng Titpawan Sritharadol Rutthapol Srichana Teerapol |
| author_facet | Sa Anongtip Sawatdee Somchai Phadoongsombut Narubodee Buatong Wilaiporn Nakpeng Titpawan Sritharadol Rutthapol Srichana Teerapol |
| author_sort | Sa Anongtip |
| collection | DOAJ |
| description | In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6-7. The viscosity was within the range of 11.9-85.9 mPa s. The surface tensions were 20.3 to 24.6 mN m-1 and the contact angles were between 19.3 and 38.7°. The assays for the iodine contents were within acceptable range (80-120 %). X-ray photoelectron spectroscopy analysis revealed the ionized form of iodine was much higher than the unionized form. The MIC and MBC values of the PVP-I sprays against Staphylococcus aureus, S. epidermidis and Pseudomonas aeruginosa were higher than that of commercial PVP-I solution. The cytotoxicity study confirmed that the PVP-I spray had lower toxic effects on keratinocytes and fibroblasts compared to the commercial PVP-I solution. The formulation containing 59 % ethanol, 18 % copovidone and 12 % PEG 400 showed good antibacterial activity. |
| format | Article |
| id | doaj-art-4e15cb4a8c8148e1bbc0032ad5c7080f |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-4e15cb4a8c8148e1bbc0032ad5c7080f2025-02-02T21:49:41ZengSciendoActa Pharmaceutica1846-95582017-06-0167216918610.1515/acph-2017-0011acph-2017-0011Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical propertiesSa Anongtip0Sawatdee Somchai1Phadoongsombut Narubodee2Buatong Wilaiporn3Nakpeng Titpawan4Sritharadol Rutthapol5Srichana Teerapol6Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hat Yai, Songkhla 90112, ThailandDrug and Cosmetic (Research and Development Unit), School of Pharmacy, Walailak University Thasala, Nakhon Si Thammarat 80161, ThailandDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hat Yai, Songkhla 90112, ThailandNanotec-PSU Excellence Center on Drug Delivery System Faculty of Pharmaceutical Sciences Prince of Songkla University, Hat Yai Songkhla 90112, ThailandNanotec-PSU Excellence Center on Drug Delivery System Faculty of Pharmaceutical Sciences Prince of Songkla University, Hat Yai Songkhla 90112, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hat Yai, Songkhla 90112, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hat Yai, Songkhla 90112, ThailandIn this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6-7. The viscosity was within the range of 11.9-85.9 mPa s. The surface tensions were 20.3 to 24.6 mN m-1 and the contact angles were between 19.3 and 38.7°. The assays for the iodine contents were within acceptable range (80-120 %). X-ray photoelectron spectroscopy analysis revealed the ionized form of iodine was much higher than the unionized form. The MIC and MBC values of the PVP-I sprays against Staphylococcus aureus, S. epidermidis and Pseudomonas aeruginosa were higher than that of commercial PVP-I solution. The cytotoxicity study confirmed that the PVP-I spray had lower toxic effects on keratinocytes and fibroblasts compared to the commercial PVP-I solution. The formulation containing 59 % ethanol, 18 % copovidone and 12 % PEG 400 showed good antibacterial activity.https://doi.org/10.1515/acph-2017-0011povidone-iodinetopical spraybioactivitycytotoxicityx-ray photoelectron spectroscopy |
| spellingShingle | Sa Anongtip Sawatdee Somchai Phadoongsombut Narubodee Buatong Wilaiporn Nakpeng Titpawan Sritharadol Rutthapol Srichana Teerapol Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties Acta Pharmaceutica povidone-iodine topical spray bioactivity cytotoxicity x-ray photoelectron spectroscopy |
| title | Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties |
| title_full | Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties |
| title_fullStr | Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties |
| title_full_unstemmed | Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties |
| title_short | Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties |
| title_sort | quantitative analysis of povidone iodine thin films by x ray photoelectron spectroscopy and their physicochemical properties |
| topic | povidone-iodine topical spray bioactivity cytotoxicity x-ray photoelectron spectroscopy |
| url | https://doi.org/10.1515/acph-2017-0011 |
| work_keys_str_mv | AT saanongtip quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties AT sawatdeesomchai quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties AT phadoongsombutnarubodee quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties AT buatongwilaiporn quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties AT nakpengtitpawan quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties AT sritharadolrutthapol quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties AT srichanateerapol quantitativeanalysisofpovidoneiodinethinfilmsbyxrayphotoelectronspectroscopyandtheirphysicochemicalproperties |