Task- and Time-Dependent Memory Enhancement by Dehydroepiandosterone in Day-Old Chicks
We have previously reported the presence of dehydroepiandosterone (DHEA) in the dayold- chick brain, and a role for it in enhanced memory formation. Here we confirm that intracerebral injections of DHEA 5 min before training on the weak passive avoidance task enhanced recall 24 hours after training....
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2001.255 |
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| Summary: | We have previously reported the presence
of dehydroepiandosterone (DHEA) in the dayold-
chick brain, and a role for it in enhanced
memory formation. Here we confirm that
intracerebral injections of DHEA 5 min before
training on the weak passive avoidance task
enhanced recall 24 hours after training. Recall
per se on an appetitive visual categorization
task was not altered by administration of
DHEA 5 min before training. However
administration of DHEA 5 min before limited
or very limited training on a visual categorization
task (20 or 10 pecks only) appeared to
enhance consolidation of this task at test 24 h
after training; reducing the latency and total
time taken to complete the test (60 pecks), while
not detrimentally altering accuracy. Moreover,
DHEA is unlikely to induce this effect via
possible anxiolytic effects because it did not
alter behavior in the open field test. We also
examined diffusion of DHEA throughout the
brain at various stages following intracerebral
injection. |
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| ISSN: | 2090-5904 1687-5443 |