The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj
We conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Each participant underwent four successive systematic...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1693247 |
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| author | Van-Thuan Hoang Thi-Loi Dao Tran Duc Anh Ly Khadidja Belhouchat Kamel Larbi Chaht Jean Gaudart Bakridine Mmadi Mrenda Tassadit Drali Saber Yezli Badriah Alotaibi Pierre-Edouard Fournier Didier Raoult Philippe Parola Vincent Pommier de Santi Philippe Gautret |
| author_facet | Van-Thuan Hoang Thi-Loi Dao Tran Duc Anh Ly Khadidja Belhouchat Kamel Larbi Chaht Jean Gaudart Bakridine Mmadi Mrenda Tassadit Drali Saber Yezli Badriah Alotaibi Pierre-Edouard Fournier Didier Raoult Philippe Parola Vincent Pommier de Santi Philippe Gautret |
| author_sort | Van-Thuan Hoang |
| collection | DOAJ |
| description | We conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Each participant underwent four successive systematic nasopharyngeal swabs before and during their stay in Saudi Arabia. Carriage of the main respiratory pathogens was assessed by PCR. 121 pilgrims were included and 93.4% reported respiratory symptoms during the study period. The acquisition of rhinovirus, coronaviruses and Staphylococcus aureus occurred soon after arrival in Saudi Arabia and rates decreased gradually after days 5 and 6. In contrast, Streptococcus pneumoniae and Klebsiella pneumoniae carriage increased progressively until the end of the stay in Saudi Arabia. Haemophilus influenzae and Moraxella catarrhalis carriage increased starting around days 12 and 13, following an initial clearance. Influenza viruses were rarely isolated. We observed an independent positive mutual association between S. aureus and rhinovirus carriage and between H. influenzae and M. catarrhalis carriage. Dual carriage of H. influenzae and M. catarrhalis was strongly associated with S. pneumoniae carriage (OR = 6.22). Finally, our model showed that M. catarrhalis carriage was negatively associated with K. pneumoniae carriage. Chronic respiratory disease was associated with symptoms of LRTI. K. pneumoniae, M. catarrhalis-S. aureus and H. influenzae-rhinovirus dual carriage was associated with LRTI symptoms. Our data suggest that RTIs at the Hajj are a result of complex interactions between a number of respiratory viruses and bacteria. |
| format | Article |
| id | doaj-art-4e0c5703dc3f49bc9dd38f4d95fa5ba1 |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-4e0c5703dc3f49bc9dd38f4d95fa5ba12025-08-20T03:17:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811701171010.1080/22221751.2019.1693247The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 HajjVan-Thuan Hoang0Thi-Loi Dao1Tran Duc Anh Ly2Khadidja Belhouchat3Kamel Larbi Chaht4Jean Gaudart5Bakridine Mmadi Mrenda6Tassadit Drali7Saber Yezli8Badriah Alotaibi9Pierre-Edouard Fournier10Didier Raoult11Philippe Parola12Vincent Pommier de Santi13Philippe Gautret14Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, INSERM, IRD, SESSTIM UMR1252, Faculty of Medicine Marseille, FranceFrench Military Centre for Epidemiology and Public Health, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceThe Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi ArabiaThe Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi ArabiaAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceIHU-Méditerranée Infection, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceAix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, FranceWe conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Each participant underwent four successive systematic nasopharyngeal swabs before and during their stay in Saudi Arabia. Carriage of the main respiratory pathogens was assessed by PCR. 121 pilgrims were included and 93.4% reported respiratory symptoms during the study period. The acquisition of rhinovirus, coronaviruses and Staphylococcus aureus occurred soon after arrival in Saudi Arabia and rates decreased gradually after days 5 and 6. In contrast, Streptococcus pneumoniae and Klebsiella pneumoniae carriage increased progressively until the end of the stay in Saudi Arabia. Haemophilus influenzae and Moraxella catarrhalis carriage increased starting around days 12 and 13, following an initial clearance. Influenza viruses were rarely isolated. We observed an independent positive mutual association between S. aureus and rhinovirus carriage and between H. influenzae and M. catarrhalis carriage. Dual carriage of H. influenzae and M. catarrhalis was strongly associated with S. pneumoniae carriage (OR = 6.22). Finally, our model showed that M. catarrhalis carriage was negatively associated with K. pneumoniae carriage. Chronic respiratory disease was associated with symptoms of LRTI. K. pneumoniae, M. catarrhalis-S. aureus and H. influenzae-rhinovirus dual carriage was associated with LRTI symptoms. Our data suggest that RTIs at the Hajj are a result of complex interactions between a number of respiratory viruses and bacteria.https://www.tandfonline.com/doi/10.1080/22221751.2019.1693247Hajjpilgrimsrespiratory tract infectionspathogen interaction |
| spellingShingle | Van-Thuan Hoang Thi-Loi Dao Tran Duc Anh Ly Khadidja Belhouchat Kamel Larbi Chaht Jean Gaudart Bakridine Mmadi Mrenda Tassadit Drali Saber Yezli Badriah Alotaibi Pierre-Edouard Fournier Didier Raoult Philippe Parola Vincent Pommier de Santi Philippe Gautret The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj Emerging Microbes and Infections Hajj pilgrims respiratory tract infections pathogen interaction |
| title | The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj |
| title_full | The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj |
| title_fullStr | The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj |
| title_full_unstemmed | The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj |
| title_short | The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj |
| title_sort | dynamics and interactions of respiratory pathogen carriage among french pilgrims during the 2018 hajj |
| topic | Hajj pilgrims respiratory tract infections pathogen interaction |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1693247 |
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