Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation

Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation

Background Diabetic nephropathy (DN) is a diabetes mellitus (DM)-induced complication that poses high morbidity and mortality risks. The Astragalus and Salvia miltiorrhiza couplet medicines (AS) are commonly employed in DN clinical treatment in China, but their clinical efficacy and potential pharma...

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Bibliographic Details
Main Authors: Huiyu Liang, Zedong Chen, Mingmin Zhu, Jingying Zhong, Shufan Lin, Jianfeng Chen, Jing Yuan, Pingping Jiang, Xiaoshan Zhao, Ya Xiao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Diabetic nephropathy
Astragalus
Salvia miltiorrhiza
meta-analysis
network pharmacology
molecular docking
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2466116
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2466116

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