Maplirpacept: a CD47 decoy receptor with minimal red blood cell binding and robust anti-tumor efficacy

Maplirpacept: a CD47 decoy receptor with minimal red blood cell binding and robust anti-tumor efficacy

IntroductionCD47 is highly expressed on cancer cells and triggers an anti-phagocytic “don’t eat me” signal when bound by the inhibitory signal regulatory protein α (SIRPα) expressed on macrophages. While CD47 blockade can mitigate tumor growth, many CD47 blockers also bind to red blood cells (RBCs),...

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Bibliographic Details
Main Authors: Mithunah Krishnamoorthy, Ruth Seelige, Christopher R. Brown, Nancy Chau, Natasja Nielsen Viller, Lisa D. S. Johnson, Emma Linderoth, Jean C. Y. Wang, Christopher P. Dillon, Keith Abayasiriwardana, Clare Lees, Mark Wong, Megan M. Kaneda, Robert A. Uger, Gloria H. Y. Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
CD47
phagocytosis
red blood cells
hematological malignances
SIRP alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518787/full
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