G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis

G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis

Abstract Altered hepatic glucose fluxes are critical during the pathogenesis of type 2 diabetes. G protein-coupled receptors represent important regulators of hepatic glucose production. Recent studies have shown that hepatocytes express GPCRs that can couple to G12/13, a subfamily of heterotrimeric...

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Main Authors: Srinivas Pittala, Dhanush Haspula, Yinghong Cui, Won-Mo Yang, Young-Bum Kim, Roger J. Davis, Allison Wing, Yaron Rotman, Owen P. McGuinness, Asuka Inoue, Jürgen Wess
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54299-7
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