Brain oscillations in bipolar disorder and lithium-induced changes
Murat İlhan Atagün Department of Psychiatry, Yıldırım Beyazıt University Medical School, Cankaya, Ankara, Turkey Abstract: Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe...
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Dove Medical Press
2016-03-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/brain-oscillations-in-bipolar-disorder-andnbsplithium-induced-changes-peer-reviewed-fulltext-article-NDT |
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| author | Atagün M |
| author_facet | Atagün M |
| author_sort | Atagün M |
| collection | DOAJ |
| description | Murat İlhan Atagün Department of Psychiatry, Yıldırım Beyazıt University Medical School, Cankaya, Ankara, Turkey Abstract: Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lithium-induced EEG changes in bipolar disorder and to discuss potential underlying factors. A literature survey about lithium-induced EEG changes in bipolar disorder was performed. Lithium consistently enhances magnitudes of brain oscillations in slow frequencies (delta and theta) in both resting-state EEG studies as well as event-related oscillations studies. Enhancement of magnitudes of beta oscillations is specific to event-related oscillations. Correlation between serum lithium levels and brain oscillations has been reported. Lithium-induced changes in brain oscillations might correspond to lithium-induced alterations in neurotransmitters, signaling cascades, plasticity, brain structure, or biophysical properties of lithium. Therefore, lithium-induced changes in brain oscillations could be promising biomarkers to assess the molecular mechanisms leading to variability in efficacy. Since the variability of lithium response in bipolar disorder is due to the genetic differences in the mechanisms involving lithium, it would be highly promising to assess the lithium-induced EEG changes as biomarkers in genetic studies. Keywords: lithium, bipolar disorder, brain oscillations, electroencephalography, biomarker |
| format | Article |
| id | doaj-art-4dfde5fa57594d07b3d75ebe1088534f |
| institution | Kabale University |
| issn | 1178-2021 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-4dfde5fa57594d07b3d75ebe1088534f2025-08-20T03:27:01ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212016-03-01Volume 12Issue 158960125867Brain oscillations in bipolar disorder and lithium-induced changesAtagün M0Department of PsychiatryMurat İlhan Atagün Department of Psychiatry, Yıldırım Beyazıt University Medical School, Cankaya, Ankara, Turkey Abstract: Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lithium-induced EEG changes in bipolar disorder and to discuss potential underlying factors. A literature survey about lithium-induced EEG changes in bipolar disorder was performed. Lithium consistently enhances magnitudes of brain oscillations in slow frequencies (delta and theta) in both resting-state EEG studies as well as event-related oscillations studies. Enhancement of magnitudes of beta oscillations is specific to event-related oscillations. Correlation between serum lithium levels and brain oscillations has been reported. Lithium-induced changes in brain oscillations might correspond to lithium-induced alterations in neurotransmitters, signaling cascades, plasticity, brain structure, or biophysical properties of lithium. Therefore, lithium-induced changes in brain oscillations could be promising biomarkers to assess the molecular mechanisms leading to variability in efficacy. Since the variability of lithium response in bipolar disorder is due to the genetic differences in the mechanisms involving lithium, it would be highly promising to assess the lithium-induced EEG changes as biomarkers in genetic studies. Keywords: lithium, bipolar disorder, brain oscillations, electroencephalography, biomarkerhttps://www.dovepress.com/brain-oscillations-in-bipolar-disorder-andnbsplithium-induced-changes-peer-reviewed-fulltext-article-NDTlithiumbipolar disorderbrain oscillationsneuroplasticitybiomarker |
| spellingShingle | Atagün M Brain oscillations in bipolar disorder and lithium-induced changes Neuropsychiatric Disease and Treatment lithium bipolar disorder brain oscillations neuroplasticity biomarker |
| title | Brain oscillations in bipolar disorder and lithium-induced changes |
| title_full | Brain oscillations in bipolar disorder and lithium-induced changes |
| title_fullStr | Brain oscillations in bipolar disorder and lithium-induced changes |
| title_full_unstemmed | Brain oscillations in bipolar disorder and lithium-induced changes |
| title_short | Brain oscillations in bipolar disorder and lithium-induced changes |
| title_sort | brain oscillations in bipolar disorder and amp nbsp lithium induced changes |
| topic | lithium bipolar disorder brain oscillations neuroplasticity biomarker |
| url | https://www.dovepress.com/brain-oscillations-in-bipolar-disorder-andnbsplithium-induced-changes-peer-reviewed-fulltext-article-NDT |
| work_keys_str_mv | AT atagunm brainoscillationsinbipolardisorderandampnbsplithiuminducedchanges |