The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells
Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an...
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MDPI AG
2024-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/21/1813 |
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| author | Snezhanna Kandrashina Ekaterina Sherstyukova Mikhail Shvedov Vladimir Inozemtsev Roman Timoshenko Alexander Erofeev Maxim Dokukin Viktoria Sergunova |
| author_facet | Snezhanna Kandrashina Ekaterina Sherstyukova Mikhail Shvedov Vladimir Inozemtsev Roman Timoshenko Alexander Erofeev Maxim Dokukin Viktoria Sergunova |
| author_sort | Snezhanna Kandrashina |
| collection | DOAJ |
| description | Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell’s elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production. |
| format | Article |
| id | doaj-art-4dfd4e3744fd4815b9897d198a4eeeda |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-4dfd4e3744fd4815b9897d198a4eeeda2025-08-20T02:13:14ZengMDPI AGCells2073-44092024-11-011321181310.3390/cells13211813The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood CellsSnezhanna Kandrashina0Ekaterina Sherstyukova1Mikhail Shvedov2Vladimir Inozemtsev3Roman Timoshenko4Alexander Erofeev5Maxim Dokukin6Viktoria Sergunova7Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, RussiaResearch laboratory of biophysics, National University of Science and Technology “MISIS”, 119049 Moscow, RussiaResearch laboratory of biophysics, National University of Science and Technology “MISIS”, 119049 Moscow, RussiaSarov Physics and Technology Institute, MEPhI, 607186 Sarov, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, RussiaRed blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell’s elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production.https://www.mdpi.com/2073-4409/13/21/1813red blood cellpHROSAFMSICMnanostructure |
| spellingShingle | Snezhanna Kandrashina Ekaterina Sherstyukova Mikhail Shvedov Vladimir Inozemtsev Roman Timoshenko Alexander Erofeev Maxim Dokukin Viktoria Sergunova The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells Cells red blood cell pH ROS AFM SICM nanostructure |
| title | The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells |
| title_full | The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells |
| title_fullStr | The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells |
| title_full_unstemmed | The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells |
| title_short | The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells |
| title_sort | effect of the acid base imbalance on the shape and structure of red blood cells |
| topic | red blood cell pH ROS AFM SICM nanostructure |
| url | https://www.mdpi.com/2073-4409/13/21/1813 |
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