Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system.
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Medicine |
| Online Access: | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001161&type=printable |
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| author | Grant A Mackenzie Ian D Plumb Sana Sambou Debasish Saha Uchendu Uchendu Bolanle Akinsola Usman N Ikumapayi Ignatius Baldeh Effua Usuf Kebba Touray Momodou Jasseh Stephen R C Howie Andre Wattiaux Ellen Lee Maria Deloria Knoll Orin S Levine Brian M Greenwood Richard A Adegbola Philip C Hill |
| author_facet | Grant A Mackenzie Ian D Plumb Sana Sambou Debasish Saha Uchendu Uchendu Bolanle Akinsola Usman N Ikumapayi Ignatius Baldeh Effua Usuf Kebba Touray Momodou Jasseh Stephen R C Howie Andre Wattiaux Ellen Lee Maria Deloria Knoll Orin S Levine Brian M Greenwood Richard A Adegbola Philip C Hill |
| author_sort | Grant A Mackenzie |
| collection | DOAJ |
| description | Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document the direct and indirect impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and radiological pneumonia in those aged 2 months and older in The Gambia, and to monitor changes in serotype-specific IPD. Here we describe how this surveillance system was set up and is being operated as a partnership between the Medical Research Council Unit and the Gambian Government. This surveillance system is expected to provide crucial information for immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings. |
| format | Article |
| id | doaj-art-4dee19c5385f4cf9b1d63cf70a13f132 |
| institution | OA Journals |
| issn | 1549-1277 1549-1676 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj-art-4dee19c5385f4cf9b1d63cf70a13f1322025-08-20T02:34:08ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762012-01-0191e100116110.1371/journal.pmed.1001161Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system.Grant A MackenzieIan D PlumbSana SambouDebasish SahaUchendu UchenduBolanle AkinsolaUsman N IkumapayiIgnatius BaldehEffua UsufKebba TourayMomodou JassehStephen R C HowieAndre WattiauxEllen LeeMaria Deloria KnollOrin S LevineBrian M GreenwoodRichard A AdegbolaPhilip C HillRoutine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document the direct and indirect impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and radiological pneumonia in those aged 2 months and older in The Gambia, and to monitor changes in serotype-specific IPD. Here we describe how this surveillance system was set up and is being operated as a partnership between the Medical Research Council Unit and the Gambian Government. This surveillance system is expected to provide crucial information for immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings.https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001161&type=printable |
| spellingShingle | Grant A Mackenzie Ian D Plumb Sana Sambou Debasish Saha Uchendu Uchendu Bolanle Akinsola Usman N Ikumapayi Ignatius Baldeh Effua Usuf Kebba Touray Momodou Jasseh Stephen R C Howie Andre Wattiaux Ellen Lee Maria Deloria Knoll Orin S Levine Brian M Greenwood Richard A Adegbola Philip C Hill Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. PLoS Medicine |
| title | Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. |
| title_full | Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. |
| title_fullStr | Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. |
| title_full_unstemmed | Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. |
| title_short | Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. |
| title_sort | monitoring the introduction of pneumococcal conjugate vaccines into west africa design and implementation of a population based surveillance system |
| url | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001161&type=printable |
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