Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9×7×6 mm, was resected. The neoplasm occurred as a complication of radiothera...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/325193 |
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| author | Prateek Kinra V. Srinivas Kavita Sinha Vibha Dutta |
| author_facet | Prateek Kinra V. Srinivas Kavita Sinha Vibha Dutta |
| author_sort | Prateek Kinra |
| collection | DOAJ |
| description | Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9×7×6 mm, was resected. The neoplasm occurred as a complication of radiotherapy (excessive cumulative radiation dose of 60 Gray) for carcinoma larynx with a latency period of three years. Postradiation spindle cell carcinoma is an uncommon disease manifesting as sarcoma in a previously irradiated field, usually with a latent period of 5 years or more. Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. The two components of the tumour were confirmed using the immunohistochemical staining (cytokeratin and vimentin). Further p53 positivity of the sarcomatous elements aided in ruling out radiation-induced nonmalignant changes of mesenchymal tissue. This paper discusses this rare tumour in a common setting. |
| format | Article |
| id | doaj-art-4de95224ac9e40689d661becf06d179c |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-4de95224ac9e40689d661becf06d179c2025-02-03T01:11:34ZengWileyCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/325193325193Post Irradiation Spindle Cell Carcinoma of Tonsillar PillarPrateek Kinra0V. Srinivas1Kavita Sinha2Vibha Dutta3Department of Pathology, Armed Forces Medical College, Pune 411040, IndiaDepartment of Pathology, Armed Forces Medical College, Pune 411040, IndiaDepartment of Pathology, Armed Forces Medical College, Pune 411040, IndiaDepartment of Pathology, Armed Forces Medical College, Pune 411040, IndiaSpindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9×7×6 mm, was resected. The neoplasm occurred as a complication of radiotherapy (excessive cumulative radiation dose of 60 Gray) for carcinoma larynx with a latency period of three years. Postradiation spindle cell carcinoma is an uncommon disease manifesting as sarcoma in a previously irradiated field, usually with a latent period of 5 years or more. Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. The two components of the tumour were confirmed using the immunohistochemical staining (cytokeratin and vimentin). Further p53 positivity of the sarcomatous elements aided in ruling out radiation-induced nonmalignant changes of mesenchymal tissue. This paper discusses this rare tumour in a common setting.http://dx.doi.org/10.1155/2011/325193 |
| spellingShingle | Prateek Kinra V. Srinivas Kavita Sinha Vibha Dutta Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar Case Reports in Medicine |
| title | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
| title_full | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
| title_fullStr | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
| title_full_unstemmed | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
| title_short | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
| title_sort | post irradiation spindle cell carcinoma of tonsillar pillar |
| url | http://dx.doi.org/10.1155/2011/325193 |
| work_keys_str_mv | AT prateekkinra postirradiationspindlecellcarcinomaoftonsillarpillar AT vsrinivas postirradiationspindlecellcarcinomaoftonsillarpillar AT kavitasinha postirradiationspindlecellcarcinomaoftonsillarpillar AT vibhadutta postirradiationspindlecellcarcinomaoftonsillarpillar |