Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression

Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression

Abstract Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra‐tumoral heterogeneity. The lack of robust in vitro models to study early tumor progression has hindered the development of effective therapies. Here, this study develops eng...

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Bibliographic Details
Main Authors: Matthew Ishahak, Rowland H. Han, Devi Annamalai, Timothy Woodiwiss, Colin McCornack, Ryan T. Cleary, Patrick A. DeSouza, Xuan Qu, Sonika Dahiya, Albert H. Kim, Jeffrey R. Millman
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
brain organoids
genetic engineering
glioblastoma
single‐cell RNA sequencing
spatial sequencing
Online Access:https://doi.org/10.1002/advs.202410110
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