Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight

Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight

Background: Obesity is a multi-cause chronic disease recognized across the lifespan, with childhood obesity prevalence rising over the past decades. Although exposome-wide association studies have identified early-life environmental drivers of child obesity, and explored the multi-omics signatures o...

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Main Authors: Congrong Wang, Brigitte Reimann, Tim S Nawrot, Dries S Martens, John Wright, Rosemary McEachan, Johanna Lepeule, Wenlun Yuan, Leda Chatzi, Marina Vafeiadi, Regina Grazuleviciene, Sandra Andrusaityte, Oliver Robinson, Jordi Sunyer, Hector Keun, Chung-Ho E. Lau, Alexandros P. Siskos, Muireann Coen, Eva Borràs, Eduard Sabidó, Juan R. González, Marta Vives-Usano, Xavier Estivill, Angel Carracedo, Carlos Ruiz-Arenas, Inés Quintela, Maribel Casas, Mark Nieuwenhuijsen, Ibon Tamayo, Kristine B Gutzkow, Cathrine Thomsen, Amrit K. Sakhi, Mariona Bustamante, Lea Maitre, Martine Vrijheid, Michelle Plusquin, Rossella Alfano
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Environment International
Subjects:
Childhood obesity
Exposome
Multi-omics
Meet-in-the-middle
MOFA
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Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025003812
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