The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes
Ophthalmic herpes is the most common infection-related cause of blindness in developing countries.Purpose: to evaluate the therapeutic efficacy, safety and tolerability of the drug Panavir® used as part of a combination therapy for herpetic superficial dendritic keratitis.Materials and methods. The...
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Real Time Ltd
2023-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/1307 |
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| author | E. V. Yani T. G. Kamenskikh E. V. Veselova T. G. Zubkova S. V. Stovbun K. E. Seliverstova V. V. Pozdnyakova M. M. Stupakova |
| author_facet | E. V. Yani T. G. Kamenskikh E. V. Veselova T. G. Zubkova S. V. Stovbun K. E. Seliverstova V. V. Pozdnyakova M. M. Stupakova |
| author_sort | E. V. Yani |
| collection | DOAJ |
| description | Ophthalmic herpes is the most common infection-related cause of blindness in developing countries.Purpose: to evaluate the therapeutic efficacy, safety and tolerability of the drug Panavir® used as part of a combination therapy for herpetic superficial dendritic keratitis.Materials and methods. The study involved 106 patients aged 18 to 65 years divided into two groups. Group 1 (54 patients; 54 eyes) received treatment with Panavir® and Acyclovir ophthalmic ointment, whilst Group 2 (52 patients; 52 eyes) received a placebo of Panavir® and Acyclovir ophthalmic ointment. The primary parameter of the efficiency was the percentage of patients achieving clinical recovery, i.e. signs of complete epithelialization of the cornea.Results. In group 2 (monotherapy), a significantly greater number of patients with mild conjunctival hyperemia was registered than in the combination therapy group 1 — 59.26 vs. 23.08 %, p < 0.001. In group 1, the proportion of patients without corneal syndrome at visits 3 and 4 was, respectively, 11.11 and 61.11 %, while in group 2 it was only 3.85 and 19.61 %, respectively.Conclusion. The drug Panavir® eye drops 0.004 % showed a high therapeutic efficiency in the combined treatment of herpetic keratitis, and good tolerance. It also reduced the time required for corneal epithelialization and conjunctiva normalization. |
| format | Article |
| id | doaj-art-4dde387eab2f4c6f9fb262254565e93e |
| institution | Kabale University |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-4dde387eab2f4c6f9fb262254565e93e2025-08-20T03:59:17ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602023-10-0116310411010.21516/2072-0076-2023-16-3-104-110618The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpesE. V. Yani0T. G. Kamenskikh1E. V. Veselova2T. G. Zubkova3S. V. Stovbun4K. E. Seliverstova5V. V. Pozdnyakova6M. M. Stupakova7Helmholtz National Medical Research Center of Eye DiseasesSaratov V.I. Razumovsky State Medical UniversitySaratov V.I. Razumovsky State Medical UniversityA.A. Smorodintsev Research Institute of InfluenzaN.N. Semenov Research Center of Chemical Physics, Russian Academy of SciencesHelmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesHelmholtz National Medical Research Center of Eye DiseasesOphthalmic herpes is the most common infection-related cause of blindness in developing countries.Purpose: to evaluate the therapeutic efficacy, safety and tolerability of the drug Panavir® used as part of a combination therapy for herpetic superficial dendritic keratitis.Materials and methods. The study involved 106 patients aged 18 to 65 years divided into two groups. Group 1 (54 patients; 54 eyes) received treatment with Panavir® and Acyclovir ophthalmic ointment, whilst Group 2 (52 patients; 52 eyes) received a placebo of Panavir® and Acyclovir ophthalmic ointment. The primary parameter of the efficiency was the percentage of patients achieving clinical recovery, i.e. signs of complete epithelialization of the cornea.Results. In group 2 (monotherapy), a significantly greater number of patients with mild conjunctival hyperemia was registered than in the combination therapy group 1 — 59.26 vs. 23.08 %, p < 0.001. In group 1, the proportion of patients without corneal syndrome at visits 3 and 4 was, respectively, 11.11 and 61.11 %, while in group 2 it was only 3.85 and 19.61 %, respectively.Conclusion. The drug Panavir® eye drops 0.004 % showed a high therapeutic efficiency in the combined treatment of herpetic keratitis, and good tolerance. It also reduced the time required for corneal epithelialization and conjunctiva normalization.https://roj.igb.ru/jour/article/view/1307herpeskeratitissolanum tuberosumpanavir® |
| spellingShingle | E. V. Yani T. G. Kamenskikh E. V. Veselova T. G. Zubkova S. V. Stovbun K. E. Seliverstova V. V. Pozdnyakova M. M. Stupakova The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes Российский офтальмологический журнал herpes keratitis solanum tuberosum panavir® |
| title | The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes |
| title_full | The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes |
| title_fullStr | The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes |
| title_full_unstemmed | The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes |
| title_short | The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes |
| title_sort | effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes |
| topic | herpes keratitis solanum tuberosum panavir® |
| url | https://roj.igb.ru/jour/article/view/1307 |
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