Protocol to denoise spatially resolved transcriptomics data utilizing optimal transport-based gene filtering algorithm

Protocol to denoise spatially resolved transcriptomics data utilizing optimal transport-based gene filtering algorithm

Summary: Spatially resolved transcriptomics (SRT) data contain intricate noise due to the diffusion of transcripts caused by tissue fixation, permeabilization, and cell lysis during the experiment. Here, we present a protocol for denoising SRT data using SpotGF, an optimal transport-based gene filte...

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Bibliographic Details
Main Authors: Lin Du, Jingmin Kang, Jie Li, Hua Qin, Yong Hou, Hai-Xi Sun
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:STAR Protocols
Subjects:
Bioinformatics
Health Sciences
Systems biology
Computer sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166725000310
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