Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer
Modern global guidelines in oncology consider treatment of various forms of breast cancer according to molecular tumor subtype. Steroid receptors, epidermal growth factor receptors, p53, Ki67 proliferative activity index and others are the key indicators of aggressiveness of malignant breast tumors....
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2014-09-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2014/N3/29-35.pdf |
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| author | El Khazhzh M.Kh. Bondarenko I.M. Aseyev O.I. Shponka I.S. Zavizion V.F. Sklyar A.S. Vinichenko L.M. Khodzhuzh M.I. Kunik A.V. Artemenko M.V. |
| author_facet | El Khazhzh M.Kh. Bondarenko I.M. Aseyev O.I. Shponka I.S. Zavizion V.F. Sklyar A.S. Vinichenko L.M. Khodzhuzh M.I. Kunik A.V. Artemenko M.V. |
| author_sort | El Khazhzh M.Kh. |
| collection | DOAJ |
| description | Modern global guidelines in oncology consider treatment of various forms of breast cancer according to molecular tumor subtype. Steroid receptors, epidermal growth factor receptors, p53, Ki67 proliferative activity index and others are the key indicators of aggressiveness of malignant breast tumors. The material for this study was the retrospective study of the standard set of breast cancer immuno¬histochemical markers (estrogen receptors, progesterone, epidermal growth factor type 2) in 8171 patients. 4 groups of patients - luminal A, luminal B, triple negative and HER2-neu positive subtypes of tumors were identified according to immunohistochemical status. We analyzed overall survival without relapse in 491 patients with breast cancer, clinical data and data of immunohistochemical studies were matched. Based on the investigation it was determined that in the early stages of the disease (1-2) luminal A subtype of cancer is often diagnosed. In the late stages the most common subtype is HER2-neu positive breast cancer. Herewith, patients with luminal A subtype of cancer have the best performance of the overall survival (OS ) (32,91±2,33 months), and the worst results were found in patients with HER2 - neu positive breast cancer (22,58±1,28 months). The data obtained determine HER2 - neu positive subtype as the most aggressive type of breast cancer, and the luminal A subtype – as the least aggressive one. |
| format | Article |
| id | doaj-art-4dda75284d554283b53f0affb03ddbf5 |
| institution | DOAJ |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-4dda75284d554283b53f0affb03ddbf52025-08-20T02:51:00ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042014-09-011932935Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancerEl Khazhzh M.Kh.0Bondarenko I.M.1Aseyev O.I.2Shponka I.S.3Zavizion V.F.4Sklyar A.S.5Vinichenko L.M.6Khodzhuzh M.I.7Kunik A.V.8Artemenko M.V. 9SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»Modern global guidelines in oncology consider treatment of various forms of breast cancer according to molecular tumor subtype. Steroid receptors, epidermal growth factor receptors, p53, Ki67 proliferative activity index and others are the key indicators of aggressiveness of malignant breast tumors. The material for this study was the retrospective study of the standard set of breast cancer immuno¬histochemical markers (estrogen receptors, progesterone, epidermal growth factor type 2) in 8171 patients. 4 groups of patients - luminal A, luminal B, triple negative and HER2-neu positive subtypes of tumors were identified according to immunohistochemical status. We analyzed overall survival without relapse in 491 patients with breast cancer, clinical data and data of immunohistochemical studies were matched. Based on the investigation it was determined that in the early stages of the disease (1-2) luminal A subtype of cancer is often diagnosed. In the late stages the most common subtype is HER2-neu positive breast cancer. Herewith, patients with luminal A subtype of cancer have the best performance of the overall survival (OS ) (32,91±2,33 months), and the worst results were found in patients with HER2 - neu positive breast cancer (22,58±1,28 months). The data obtained determine HER2 - neu positive subtype as the most aggressive type of breast cancer, and the luminal A subtype – as the least aggressive one.http://medpers.dsma.dp.ua/issues/2014/N3/29-35.pdfbreast cancerimmunohistochemical statusdiagnosticsclinical progressionoverall survival |
| spellingShingle | El Khazhzh M.Kh. Bondarenko I.M. Aseyev O.I. Shponka I.S. Zavizion V.F. Sklyar A.S. Vinichenko L.M. Khodzhuzh M.I. Kunik A.V. Artemenko M.V. Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer Medičnì Perspektivi breast cancer immunohistochemical status diagnostics clinical progression overall survival |
| title | Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer |
| title_full | Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer |
| title_fullStr | Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer |
| title_full_unstemmed | Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer |
| title_short | Peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer |
| title_sort | peculiarities of diagnostics and clinical course of different immunohistochemical subtypes of breast cancer |
| topic | breast cancer immunohistochemical status diagnostics clinical progression overall survival |
| url | http://medpers.dsma.dp.ua/issues/2014/N3/29-35.pdf |
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