Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis

Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis

Abstract Inclusion body myositis (IBM) is an inflammatory myopathy that displays proximal and distal muscle weakness. At the histopathological level, the muscles of IBM patients show inflammatory infiltrates, rimmed vacuoles and mitochondrial changes. The etiology of IBM remains unknown, and there i...

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Main Authors: Judith Cantó-Santos, Laura Valls-Roca, Ester Tobías, Francesc Josep García-García, Mariona Guitart-Mampel, Félix Andújar-Sánchez, Adrià Vilaseca-Capel, Anna Esteve-Codina, Beatriz Martín-Mur, Joan Padrosa, Emma Peruga, Irene Madrigal, Paula Segalés, Carmen García-Ruiz, José Carlos Fernández-Checa, Pedro J. Moreno-Lozano, Albert Selva O’Callaghan, Ana Sevilla, José César Milisenda, Glòria Garrabou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Acta Neuropathologica Communications
Subjects:
Inclusion body myositis (IBM)
iPSC
Myotubes
Inflammation
Autophagy
Mitochondria
Online Access:https://doi.org/10.1186/s40478-025-01933-0
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https://doi.org/10.1186/s40478-025-01933-0

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